MIR1266

Summary

MIR1266 (microRNA 1266, HGNC:35334) is a microRNA gene on chromosome 15q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302202 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35334
Approved symbol	MIR1266
Name	microRNA 1266
Location	15q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1266
Ensembl gene	ENSG00000221052
Ensembl biotype	miRNA
Entrez	100302202
RNAcentral	URS000075C31A — miRNA, 84 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408125

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408125 — 1 exons

Exon	Start	End
ENSE00001564760	52277117	52277200

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 76.79.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.79	gold quality
heart left ventricle	UBERON:0002084	76.35	gold quality
monocyte	CL:0000576	75.38	gold quality
heart	UBERON:0000948	74.56	gold quality
lung	UBERON:0002048	73.59	gold quality
body of pancreas	UBERON:0001150	72.33	gold quality
gastrocnemius	UBERON:0001388	70.40	gold quality
endometrium	UBERON:0001295	69.66	gold quality
ectocervix	UBERON:0012249	69.49	gold quality
stomach	UBERON:0000945	69.13	gold quality
urinary bladder	UBERON:0001255	68.39	gold quality
body of stomach	UBERON:0001161	68.08	gold quality
thoracic mammary gland	UBERON:0005200	67.79	gold quality
upper lobe of left lung	UBERON:0008952	67.53	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.51	gold quality
transverse colon	UBERON:0001157	67.02	gold quality
liver	UBERON:0002107	66.62	gold quality
intestine	UBERON:0000160	66.39	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.84	gold quality
minor salivary gland	UBERON:0001830	65.41	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.18	gold quality
esophagus mucosa	UBERON:0002469	65.17	gold quality
right frontal lobe	UBERON:0002810	64.75	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.66	gold quality
skin of abdomen	UBERON:0001416	64.51	gold quality
tibial artery	UBERON:0007610	64.44	gold quality
cerebellar hemisphere	UBERON:0002245	64.39	gold quality
myometrium	UBERON:0001296	64.26	gold quality
corpus callosum	UBERON:0002336	63.95	gold quality
anterior cingulate cortex	UBERON:0009835	63.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• MiR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting TERT. (PMID:24481448)
• high miR-1266 levels might be a significant prognostic factor for recurrence/metastasis occurrence and tamoxifen response in estrogen receptor positive breast cancer cases. (PMID:25640367)
• miR-1266 could inhibit cell proliferation and progression of papillary thyroid carcinoma via targeting FGFR2. (PMID:29917195)
• Low miR1266 expression is associated with Prostate Cancer. (PMID:30141307)
• High expression serum miR-1266 had lower overall survival rates than patients with miR-1266 low expression. MiR-1266 promoted cell viability, proliferation, migration and invasion by targeting DAB2IP. And miR-1266 could promote tumorigenesis in vivo. In conclusion, miR-1266 could be used as a new biomarker for diagnosis, prediction and treatment of cervical cancer in the future. (PMID:30261286)
• Low expression of microRNA-1266 promotes the occurrence and progression of colorectal cancer by directly targeting FTO. (PMID:30556861)
• Effect of miR-1266 on proliferation, invasion and migration of laryngeal squamous cell carcinoma by targeting CCL18. (PMID:31820618)
• miR-1266-3p Suppresses Epithelial-Mesenchymal Transition in Colon Cancer by Targeting P4HA3. (PMID:35433237)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.