MIR1267

Summary

MIR1267 (microRNA 1267, HGNC:35335) is a microRNA gene on chromosome 13q33.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302286 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35335
Approved symbol	MIR1267
Name	microRNA 1267
Location	13q33.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1267
Ensembl gene	ENSG00000221650
Ensembl biotype	miRNA
Entrez	100302286
RNAcentral	URS000075DCBB — miRNA, 78 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408723

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408723 — 1 exons

Exon	Start	End
ENSE00001565358	107531171	107531248

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 94.58.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	94.58	gold quality
kidney	UBERON:0002113	85.98	gold quality
adrenal tissue	UBERON:0018303	79.04	gold quality
islet of Langerhans	UBERON:0000006	76.81	gold quality
calcaneal tendon	UBERON:0003701	76.08	gold quality
blood	UBERON:0000178	75.57	gold quality
liver	UBERON:0002107	75.02	gold quality
stomach	UBERON:0000945	74.86	gold quality
endometrium	UBERON:0001295	74.74	gold quality
intestine	UBERON:0000160	74.18	gold quality
bone marrow	UBERON:0002371	73.78	gold quality
heart	UBERON:0000948	73.33	gold quality
heart left ventricle	UBERON:0002084	72.23	gold quality
corpus callosum	UBERON:0002336	72.19	gold quality
gastrocnemius	UBERON:0001388	72.09	gold quality
ascending aorta	UBERON:0001496	70.68	gold quality
lung	UBERON:0002048	70.51	gold quality
prefrontal cortex	UBERON:0000451	69.37	gold quality
right lobe of liver	UBERON:0001114	69.20	gold quality
thoracic aorta	UBERON:0001515	68.79	gold quality
body of stomach	UBERON:0001161	68.70	gold quality
tibial artery	UBERON:0007610	66.91	gold quality
Ammon’s horn	UBERON:0001954	66.73	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.05	gold quality
anterior cingulate cortex	UBERON:0009835	65.80	gold quality
nucleus accumbens	UBERON:0001882	65.71	gold quality
substantia nigra	UBERON:0002038	65.66	gold quality
left adrenal gland	UBERON:0001234	65.50	gold quality
multicellular organism	UBERON:0000468	65.10	gold quality
left coronary artery	UBERON:0001626	65.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The findings suggest a probable tumor suppressor role for miR-1267 and miR-2276 in breast tumor initiation and progression, but a probable promoting role for them in invasion and metastasis. (PMID:27293058)
• Long Noncoding RNA LINC01554 Inhibits the Progression of NSCLC Progression by Functioning as a ceRNA for miR-1267 and Regulating ING3/Akt/mTOR Pathway. (PMID:35845928)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.