MIR1268A

Summary

MIR1268A (microRNA 1268a, HGNC:35336) is a microRNA gene on chromosome 15q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302233 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35336
Approved symbol	MIR1268A
Name	microRNA 1268a
Location	15q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1268
Ensembl gene	ENSG00000221641
Ensembl biotype	miRNA
Entrez	100302233
RNAcentral	URS000075D69C — miRNA, 52 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408714

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408714 — 1 exons

Exon	Start	End
ENSE00001809015	22225278	22225329

Expression profiles

Bgee: expression breadth broad, 69 present calls, max score 79.09.

Top tissues by expression

69 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	79.09	gold quality
prefrontal cortex	UBERON:0000451	76.28	gold quality
placenta	UBERON:0001987	75.76	gold quality
gastrocnemius	UBERON:0001388	74.63	gold quality
blood	UBERON:0000178	74.36	gold quality
islet of Langerhans	UBERON:0000006	74.13	gold quality
transverse colon	UBERON:0001157	73.92	gold quality
colon	UBERON:0001155	72.87	gold quality
Ammon’s horn	UBERON:0001954	72.69	gold quality
heart left ventricle	UBERON:0002084	72.52	gold quality
right lobe of liver	UBERON:0001114	72.07	gold quality
right lung	UBERON:0002167	70.92	gold quality
tibial artery	UBERON:0007610	70.73	gold quality
body of pancreas	UBERON:0001150	70.09	gold quality
body of stomach	UBERON:0001161	69.57	gold quality
left adrenal gland	UBERON:0001234	69.13	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.91	gold quality
ascending aorta	UBERON:0001496	68.90	gold quality
myometrium	UBERON:0001296	68.87	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.49	gold quality
adult mammalian kidney	UBERON:0000082	68.47	gold quality
left coronary artery	UBERON:0001626	68.47	gold quality
right adrenal gland	UBERON:0001233	68.43	gold quality
descending thoracic aorta	UBERON:0002345	68.32	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.23	gold quality
nucleus accumbens	UBERON:0001882	68.22	gold quality
right atrium auricular region	UBERON:0006631	68.11	gold quality
adrenal gland	UBERON:0002369	67.81	gold quality
putamen	UBERON:0001874	67.70	gold quality
body of uterus	UBERON:0009853	67.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Study showed that the rs28599926 polymorphism of miR- 1268a might modify hepatocellular carcinoma (HCC) risk and prognosis related to AFB1 exposure. (PMID:26152337)
• Melanoma stem cells promote metastasis via exosomal miR-1268a inactivation of autophagy. (PMID:36182945)
• miR-1268a Regulates Fatty Acid Metabolism by Targeting CD36 in Angiotensin II-induced Heart Failure. (PMID:38619643)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.