MIR1268B

Summary

MIR1268B (microRNA 1268b, HGNC:41581) is a microRNA gene on chromosome 17q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616121 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41581
Approved symbol	MIR1268B
Name	microRNA 1268b
Location	17q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1268b
Ensembl gene	ENSG00000265561
Ensembl biotype	miRNA
Entrez	100616121
RNAcentral	URS000075CD61 — ncRNA, 50 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579691

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579691 — 1 exons

Exon	Start	End
ENSE00002690716	80098828	80098877

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 86.58.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	86.58	gold quality
muscle of leg	UBERON:0001383	76.06	gold quality
blood	UBERON:0000178	75.57	gold quality
gastrocnemius	UBERON:0001388	73.12	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.19	gold quality
urinary bladder	UBERON:0001255	70.46	gold quality
body of pancreas	UBERON:0001150	70.44	gold quality
esophagus mucosa	UBERON:0002469	69.99	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.65	gold quality
body of stomach	UBERON:0001161	69.55	gold quality
ascending aorta	UBERON:0001496	69.35	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.75	gold quality
skin of abdomen	UBERON:0001416	67.36	gold quality
amygdala	UBERON:0001876	67.28	gold quality
tibial artery	UBERON:0007610	67.11	gold quality
caudate nucleus	UBERON:0001873	66.92	gold quality
body of uterus	UBERON:0009853	66.37	gold quality
skin of leg	UBERON:0001511	66.06	gold quality
hypothalamus	UBERON:0001898	66.02	gold quality
Ammon’s horn	UBERON:0001954	65.39	gold quality
left lobe of thyroid gland	UBERON:0001120	65.21	gold quality
myometrium	UBERON:0001296	65.09	gold quality
pituitary gland	UBERON:0000007	64.83	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.72	gold quality
left ovary	UBERON:0002119	64.63	gold quality
ovary	UBERON:0000992	64.52	gold quality
tibial nerve	UBERON:0001323	63.73	gold quality
prostate gland	UBERON:0002367	63.66	gold quality
right lobe of thyroid gland	UBERON:0001119	63.28	gold quality
omental fat pad	UBERON:0010414	63.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Identification of a Novel Angiogenesis Signalling circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the Regulatory Effects of TMP-PF In Vitro. (PMID:36770940)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.