MIR1269A

Summary

MIR1269A (microRNA 1269a, HGNC:35337) is a microRNA gene on chromosome 4q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302177 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35337
Approved symbol	MIR1269A
Name	microRNA 1269a
Location	4q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1269
Ensembl gene	ENSG00000221563
Ensembl biotype	miRNA
Entrez	100302177
RNAcentral	URS000075B86F — miRNA, 105 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408636

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408636 — 1 exons

Exon	Start	End
ENSE00001565271	66276824	66276928

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 77.49.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left adrenal gland cortex	UBERON:0035825	77.49	gold quality
right lobe of liver	UBERON:0001114	74.35	gold quality
gastrocnemius	UBERON:0001388	72.65	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.44	gold quality
blood	UBERON:0000178	70.05	gold quality
thoracic aorta	UBERON:0001515	69.91	gold quality
ascending aorta	UBERON:0001496	68.86	gold quality
granulocyte	CL:0000094	68.12	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.76	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.84	gold quality
skin of leg	UBERON:0001511	66.72	gold quality
nucleus accumbens	UBERON:0001882	66.45	gold quality
skin of abdomen	UBERON:0001416	66.20	gold quality
tibial nerve	UBERON:0001323	65.55	gold quality
right frontal lobe	UBERON:0002810	64.62	gold quality
lung	UBERON:0002048	63.49	gold quality
corpus callosum	UBERON:0002336	62.28	gold quality
esophagus mucosa	UBERON:0002469	61.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Study indicated that overexpression of miR-1269 promotes cell proliferation in hepatocellular carcinoma (HCC) through directly suppressing FOXO1, and functions as an oncomiR in HCC. (PMID:25472505)
• miR-1269a significantly increases the ability of CRC cells to invade and metastasize in vivo. TGF-beta activates miR-1269 via Sox4, while miR-1269a enhances TGF-beta signalling by targeting Smad7 and HOXD10, hence forming a positive feedback loop. (PMID:25872451)
• miR-1269a SNP plays a role in the occurrence and process of hepatocellular carcinoma and the relevant mechanism, in accompany with the discovery of the novel target genes of miR-1269a. (PMID:28081866)
• miR-214-5p and miR-1269 could be considered as early biomarkers for tracking the progress of liver fibrosis to hepatocellular carcinoma. (PMID:28638226)
• The novel miR-1269b-regulated protein SVEP1 induces hepatocellular carcinoma proliferation and metastasis likely through the PI3K/Akt pathway. (PMID:32371982)
• Serum exosomal miR-1269a serves as a diagnostic marker and plays an oncogenic role in non-small cell lung cancer. (PMID:33107700)
• A novel prognostic mRNA/miRNA signature for esophageal cancer and its immune landscape in cancer progression. (PMID:33463006)
• Association between Genetic Polymorphisms of miR-1307, miR- 1269, miR-3117 and Breast Cancer Risk in a Sample of South East Iranian Women. (PMID:33507700)
• Hsa-miR-1269a up-regulation fosters the malignant progression of esophageal squamous cell carcinoma via targeting FAM46C. (PMID:37467675)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.