MIR1269B

Summary

MIR1269B (microRNA 1269b, HGNC:41787) is a microRNA gene on chromosome 17p12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616494 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41787
Approved symbol	MIR1269B
Name	microRNA 1269b
Location	17p12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1269b
Ensembl gene	ENSG00000265503
Ensembl biotype	miRNA
Entrez	100616494
RNAcentral	URS000075EE26 — miRNA, 75 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580405

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580405 — 1 exons

Exon	Start	End
ENSE00002711350	12917268	12917342

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 90.14.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	90.14	gold quality
calcaneal tendon	UBERON:0003701	78.74	gold quality
islet of Langerhans	UBERON:0000006	75.45	gold quality
gastrocnemius	UBERON:0001388	75.25	gold quality
monocyte	CL:0000576	75.03	gold quality
urinary bladder	UBERON:0001255	74.81	gold quality
saliva-secreting gland	UBERON:0001044	72.68	gold quality
endometrium	UBERON:0001295	72.62	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.40	gold quality
blood	UBERON:0000178	71.29	gold quality
stomach	UBERON:0000945	70.27	gold quality
heart	UBERON:0000948	69.87	gold quality
lung	UBERON:0002048	68.64	gold quality
body of stomach	UBERON:0001161	68.14	gold quality
liver	UBERON:0002107	67.82	gold quality
right lobe of liver	UBERON:0001114	67.51	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.26	gold quality
tibial artery	UBERON:0007610	66.63	gold quality
right atrium auricular region	UBERON:0006631	66.21	gold quality
skin of abdomen	UBERON:0001416	66.20	gold quality
intestine	UBERON:0000160	65.96	gold quality
corpus callosum	UBERON:0002336	65.69	gold quality
colon	UBERON:0001155	65.56	gold quality
body of pancreas	UBERON:0001150	65.42	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.15	gold quality
minor salivary gland	UBERON:0001830	65.11	gold quality
Ammon’s horn	UBERON:0001954	64.94	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.92	gold quality
transverse colon	UBERON:0001157	64.40	gold quality
fallopian tube	UBERON:0003889	64.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• HBx activates NF-kappaB to promote the expression of miR1269b, which augments CDC40 expression, contributing to malignancy in hepatocellular cancer. (PMID:27349221)
• The genetic variants of miR-146a and miR-1269b are biomarkers against the development of OPLs and OPSCC. (PMID:27525378)
• MicroRNA-1269b inhibits gastric cancer development through regulating methyltransferase-like 3 (METTL3). (PMID:33818282)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.