MIR127

Summary

MIR127 (microRNA 127, HGNC:31509) is a microRNA gene on chromosome 14q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406914 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31509
Approved symbol	MIR127
Name	microRNA 127
Location	14q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-127
Ensembl gene	ENSG00000207608
Ensembl biotype	miRNA
OMIM	611709
Entrez	406914
RNAcentral	URS0000007340 — miRNA, 97 nt, 41 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384876

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384876 — 1 exons

Exon	Start	End
ENSE00001499883	100882979	100883075

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 70.91.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	70.91	gold quality
minor salivary gland	UBERON:0001830	66.31	gold quality
right frontal lobe	UBERON:0002810	65.18	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.36	gold quality
vagina	UBERON:0000996	61.68	gold quality
amygdala	UBERON:0001876	50.02	gold quality
substantia nigra	UBERON:0002038	49.68	gold quality
right testis	UBERON:0004534	40.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ESRRG, JUN, NR0B2, TP53

Literature-anchored findings (GeneRIF, showing 40)

• MiR-127 levels were significantly higher in testicular than in central nervous system and in nodal diffuse large B-cell lymphomas (PMID:19287466)
• Data provide evidence that hsa-miR-127 is involved in B-cell differentiation process through posttranscriptional regulation of BLIMP1 and XBP1. (PMID:19530237)
• the miR-433/127 loci may have evolved from a common gene of origin in mammals (PMID:19946636)
• miR-127-5p targets the 3’UTR of beta-F1-ATPase mRNA (beta-mRNA) significantly reducing its translational efficiency. (PMID:22433606)
• This is the first report elucidating a feedback regulation between miR-127 and the TGFbeta/c-Jun cascade in hepatocellular carcinoma migration via MMP13. (PMID:23762330)
• The ectopic expression of miR-433 and mir-127 in gastric cancer cell lines inhibits cell proliferation, cell migration and invasion by interacting with the mRNA encoding oncogenic factors KRAS and MAPK4 respectively. (PMID:23880861)
• MicroRNA-127-5p is an important regulator of MMP-13 in human chondrocytes and may contribute to the development of osteoarthritis. (PMID:24022470)
• Loss of MIR127 expression is associated with breast cancer. (PMID:24155205)
• Circulating miR-127-3p, miR-376a and miR-652 were found to be associated with breast cancer. (PMID:24194846)
• miR-127 has a role as a tumor suppressor that modulates the oncogene BCL6. (PMID:24282530)
• the present study found a positive correlation between the levels of miR-127-3p and the cell migration and invasion abilities in several human glioblastoma cell lines. (PMID:24604520)
• The miR-127 plays a tumor-suppressor role and can serve as a potential diagnostic biomarker for Hepatocellular Carcinoma Cells(HCC). (PMID:24854842)
• Breast cancer patients with low miR-127 showed poorer overall survival than those with high miR-127. (PMID:25477702)
• Plasma miR-127 may be a promising tumor marker for cervical cancer. (PMID:25701838)
• Glioma cell adriamycin resistance can be reversed by silencing expression of microRNA-127. (PMID:26261488)
• Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6. (PMID:26655997)
• Overall, the results revealed that miR-127-3p acts as a tumor suppressor and that its down-regulation in cancer may contribute to OS progression and metastasis. (PMID:26707641)
• miR-127-5p suppressed NF-kappaB activity by directly targeting BLVRB in hepatocellular carcinoma cells. (PMID:26708147)
• Study identified that miR-127-5p targets the 3’ UTR of osteoarthritis (OA) mRNA to down-regulate the expression of OPN. In OA, the down-expressed miR-127-5p allows the expression of OPN, which mediates the establishment and development of OA. (PMID:27126955)
• Low miR127 expression is associated with pancreatic cancer. (PMID:27571739)
• Subsequent BAG5 upregulation ameliorated the tumor-suppressive effects of miR-127-3p overexpression in epithelial ovarian cancer (EOC). In conclusion, miR-127-3p functions as a tumor suppressor in EOC, and its influence on EOC is directly through regulation of BAG5. (PMID:27571744)
• FMNL3, the target gene of miR-127, is upregulated and acting as an oncogene in ESCC (PMID:27645894)
• MIR-127 and MIR-125b-1 are hypermethylated in breast cancer patients displaying metastases. (PMID:27998789)
• Low miR127 expression is associated with intervertebral disc degeneration. (PMID:28559201)
• MALAT1 could directly bind to miR-127-5p to inhibit its expression, so as to rescue OPN expression and promote chondrocyte proliferation through PI3K/Akt pathway. (PMID:28590075)
• Results indicate that re-expression of miR-127-3p and miR-376a-3p induces a strong tumor suppressor effect in GCTSC, which is partially mediated via COA1 and PDIA6. (PMID:28866093)
• Results show that the plasma miR-127 level was significantly downregulated in acute pancreatitis (AP) patients with respiratory failure compared with the healthy volunteers and those without respiratory failure. MiR-127 might serve as a potential marker for the identification of AP with lung injury (LI). (PMID:29434409)
• MiR-127-3p inhibits cell growth and invasiveness by targeting ITGA6 in human osteosarcoma. (PMID:29573114)
• Increased expression of hsa-mir-127 and decreased expression of REPIN1 were both associated with poor overall survival (PMID:29979259)
• Circular RNA USP45 decreases osteogenesis in bone glucocorticoid-induced osteonecrosis of femoral head by sponging miR-127-5p through PTEN/AKT signal pathway. (PMID:30579595)
• miR-127-3p was downregulated in oral squamous cell carcinoma (OSCC) tissues and was associated with malignant clinicopathological features and poor prognosis. KIF3B was confirmed to be a direct target of miR-127-3p. Upregulation of KIF3B observed in OSCC promoted tumorigenesis. miR-127-3p targeted KIF3B to inhibit the development of OSCC by suppressing cell proliferation, migration and invasion. (PMID:30720171)
• long noncoding RNA POU3 F3, induced by transcription factor SP1, acts as an oncogene in the cervical cancer tumorigenesis via regulating miR-127-5p/FOXD1 axis. (PMID:31252264)
• MiR-127 inhibits ovarian cancer migration and invasion by up-regulating ITGA6. (PMID:31345018)
• Transcriptional downregulation of miR-127-3p by CTCF promotes prostate cancer bone metastasis by targeting PSMB5. (PMID:31562641)
• A Novel Bioengineered miR-127 Prodrug Suppresses the Growth and Metastatic Potential of Triple-Negative Breast Cancer Cells. (PMID:31694904)
• MicroRNA-127 Inhibits the Progression of Melanoma by Downregulating Delta-Like Homologue 1. (PMID:32051829)
• Highly expressed lncRNA FOXD3-AS1 promotes non-small cell lung cancer progression via regulating miR-127-3p/mediator complex subunit 28 axis. (PMID:32196603)
• Circular RNA circ_0103552 promotes the invasion and migration of thyroid carcinoma cells by sponging miR-127. (PMID:32196608)
• FOXD3-AS1 Contributes to the Progression of Melanoma Via miR-127-3p/FJX1 Axis. (PMID:32354225)
• MicroRNA-127-5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency. (PMID:32391592)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir127	ENSMUSG00000070076
rattus_norvegicus	Mir127	ENSRNOG00000036496

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.