MIR1270

Summary

MIR1270 (microRNA 1270, HGNC:35338) is a microRNA gene on chromosome 19p12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302179 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35338
Approved symbol	MIR1270
Name	microRNA 1270
Location	19p12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1270, hsa-mir-1270-2
Ensembl gene	ENSG00000238517
Ensembl biotype	miRNA
Entrez	100302179
RNAcentral	URS000075E4AE — miRNA, 83 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000459320

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000459320 — 1 exons

Exon	Start	End
ENSE00001808693	20399272	20399354

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 85.88.

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	85.88	gold quality
skeletal muscle tissue	UBERON:0001134	82.23	gold quality
lymph node	UBERON:0000029	80.49	gold quality
endometrium	UBERON:0001295	80.16	gold quality
blood	UBERON:0000178	76.98	gold quality
islet of Langerhans	UBERON:0000006	75.24	gold quality
muscle of leg	UBERON:0001383	73.66	gold quality
prefrontal cortex	UBERON:0000451	73.15	gold quality
kidney	UBERON:0002113	71.58	gold quality
gastrocnemius	UBERON:0001388	71.32	gold quality
adult mammalian kidney	UBERON:0000082	71.26	gold quality
metanephros cortex	UBERON:0010533	70.93	gold quality
stomach	UBERON:0000945	70.03	gold quality
body of stomach	UBERON:0001161	69.63	gold quality
heart	UBERON:0000948	69.27	gold quality
heart left ventricle	UBERON:0002084	69.18	gold quality
right atrium auricular region	UBERON:0006631	69.09	gold quality
left adrenal gland	UBERON:0001234	68.47	gold quality
body of pancreas	UBERON:0001150	68.02	gold quality
putamen	UBERON:0001874	67.86	gold quality
right lobe of thyroid gland	UBERON:0001119	67.84	gold quality
left uterine tube	UBERON:0001303	67.69	gold quality
tibial artery	UBERON:0007610	67.67	gold quality
substantia nigra	UBERON:0002038	67.66	gold quality
ascending aorta	UBERON:0001496	67.65	gold quality
left adrenal gland cortex	UBERON:0035825	67.53	gold quality
thoracic mammary gland	UBERON:0005200	67.42	gold quality
thoracic aorta	UBERON:0001515	67.07	gold quality
left coronary artery	UBERON:0001626	66.78	gold quality
adrenal gland	UBERON:0002369	66.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 17)

• Our findings support the hypothesis that hsa-miR-1270 suppresses the production of TAP2 by binding to this SNP in the 3’-UTR of this gene (PMID:29205500)
• MiR-1270 is upregulated in osteosarcoma.MiR-1270 was associated with poor clinical outcomes and shorter overall survival of osteosarcoma patients. (PMID:29774985)
• MIR1270 down-regulation suppresses papillary cancer cell development both in vitro and in vivo. (PMID:30551495)
• Silencing of APAF1 reduced the sensitivity of bladder cancer cells to cisplatin chemotherapy. Furthermore, Circular RNA Cdr1as could directly sponge miR-1270 and abolish its effect on APAF1. (PMID:31131537)
• Hsa-circRNA-103809 Promotes Hepatocellular Carcinoma Development via MicroRNA-1270/PLAG1 Like Zinc Finger 2 Axis. (PMID:32683589)
• Circ_0001247 functions as a miR-1270 sponge to accelerate cervical cancer progression by up-regulating ZEB2 expression level. (PMID:33386495)
• Long non-coding RNA GLIDR accelerates the tumorigenesis of lung adenocarcinoma by miR-1270/TCF12 axis. (PMID:34369267)
• miR-1270 enhances the proliferation, migration, and invasion of osteosarcoma via targeting cingulin. (PMID:34873899)
• LncRNA HCG11 represses ovarian cancer cell growth via AKT signaling pathway. (PMID:35016264)
• Knockdown of long non-coding RNA SNHG8 suppresses the progression of esophageal cancer by regulating miR-1270/BACH1 axis. (PMID:35067159)
• LncRNA KCNQ1OT1-mediated cervical cancer progression by sponging miR-1270 as a ceRNA of LOXL2 through PI3k/Akt pathway. (PMID:35218109)
• Downregulation of miR-1270 mediates endothelial progenitor cell function in preeclampsia: Role for ATM in the Src/VE-cadherin axis. (PMID:35648632)
• MiR-330-5p and miR-1270 target essential components of RNA polymerase I transcription and exhibit a novel tumor suppressor role in lung adenocarcinoma. (PMID:36253542)
• Hsa_circ_0128846 knockdown attenuates the progression of pancreatic cancer by targeting miR-1270/NR3C1 axis. (PMID:36797317)
• Circ_0001825 promotes osteogenic differentiation in human-derived mesenchymal stem cells via miR-1270/SMAD5 axis. (PMID:37674252)
• The homologous tumor-derived-exosomes loaded with miR-1270 selectively enhanced the suppression effect for colorectal cancer cells. (PMID:38197582)
• Long noncoding RNA TMPO-AS1 accelerates glycolysis by regulating the miR-1270/PKM2 axis in colorectal cancer. (PMID:38383342)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.