MIR1272

Summary

MIR1272 (microRNA 1272, HGNC:35339) is a microRNA gene on chromosome 15q22.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302184 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35339
Approved symbol	MIR1272
Name	microRNA 1272
Location	15q22.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1272
Ensembl gene	ENSG00000221033
Ensembl biotype	miRNA
Entrez	100302184
RNAcentral	URS0000759D3E — miRNA, 129 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408106

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408106 — 1 exons

Exon	Start	End
ENSE00001564741	64762387	64762515

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 80.52.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	80.52	gold quality
mucosa of stomach	UBERON:0001199	78.74	gold quality
blood	UBERON:0000178	75.26	gold quality
gastrocnemius	UBERON:0001388	71.06	gold quality
tibial artery	UBERON:0007610	70.98	gold quality
popliteal artery	UBERON:0002250	70.96	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.46	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.54	gold quality
lower esophagus	UBERON:0013473	69.50	gold quality
body of pancreas	UBERON:0001150	69.49	gold quality
stomach	UBERON:0000945	69.40	gold quality
adrenal tissue	UBERON:0018303	69.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.17	gold quality
esophagus	UBERON:0001043	69.03	gold quality
heart left ventricle	UBERON:0002084	68.88	gold quality
ascending aorta	UBERON:0001496	68.69	gold quality
thoracic aorta	UBERON:0001515	68.69	gold quality
colon	UBERON:0001155	68.53	gold quality
body of stomach	UBERON:0001161	68.10	gold quality
urinary bladder	UBERON:0001255	67.90	gold quality
transverse colon	UBERON:0001157	67.49	gold quality
heart	UBERON:0000948	67.17	gold quality
myometrium	UBERON:0001296	66.89	gold quality
fundus of stomach	UBERON:0001160	66.87	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.64	gold quality
left coronary artery	UBERON:0001626	66.48	gold quality
vagina	UBERON:0000996	66.44	gold quality
esophagus mucosa	UBERON:0002469	66.36	gold quality
body of uterus	UBERON:0009853	65.83	gold quality
omental fat pad	UBERON:0010414	65.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR-1272 Exerts Tumor-Suppressive Functions in Prostate Cancer via HIP1 Suppression. (PMID:32069895)
• The emerging role of the MiR-1272-ADAM9-CDCP1 signaling pathway in the progression of glioma. (PMID:33260155)
• miR-515-3p, miR-623, miR-1272 and Notch3 protein as new biomarkers of Hepatocellular carcinoma. (PMID:34954928)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.