MIR1273C

Summary

MIR1273C (microRNA 1273c, HGNC:38173) is a microRNA gene on chromosome 6q25.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422821 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38173
Approved symbol	MIR1273C
Name	microRNA 1273c
Location	6q25.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1273c
Ensembl gene	ENSG00000264814
Ensembl biotype	miRNA
Entrez	100422821
RNAcentral	URS000075D0DC — ncRNA, 77 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578669

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578669 — 1 exons

Exon	Start	End
ENSE00002692779	154853360	154853436

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 79.87.

Top tissues by expression

63 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	79.87	gold quality
gastrocnemius	UBERON:0001388	73.99	gold quality
monocyte	CL:0000576	73.75	gold quality
stomach	UBERON:0000945	73.05	gold quality
islet of Langerhans	UBERON:0000006	72.63	gold quality
blood	UBERON:0000178	72.15	gold quality
heart	UBERON:0000948	71.57	gold quality
right atrium auricular region	UBERON:0006631	69.38	gold quality
body of stomach	UBERON:0001161	68.47	gold quality
Ammon’s horn	UBERON:0001954	68.42	gold quality
tibial artery	UBERON:0007610	68.33	gold quality
endometrium	UBERON:0001295	68.28	gold quality
spleen	UBERON:0002106	68.02	gold quality
right frontal lobe	UBERON:0002810	67.32	gold quality
body of pancreas	UBERON:0001150	66.35	gold quality
fundus of stomach	UBERON:0001160	66.26	gold quality
anterior cingulate cortex	UBERON:0009835	65.98	gold quality
liver	UBERON:0002107	65.79	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.77	gold quality
frontal cortex	UBERON:0001870	65.25	gold quality
thoracic aorta	UBERON:0001515	65.12	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.96	gold quality
putamen	UBERON:0001874	64.90	gold quality
right lobe of liver	UBERON:0001114	64.89	gold quality
ascending aorta	UBERON:0001496	64.46	gold quality
endocervix	UBERON:0000458	63.61	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.56	gold quality
skin of abdomen	UBERON:0001416	63.52	gold quality
substantia nigra	UBERON:0002038	63.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.