MIR1273H

Summary

MIR1273H (microRNA 1273h, HGNC:49973) is a microRNA gene on chromosome 16p12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466247 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49973
Approved symbol	MIR1273H
Name	microRNA 1273h
Location	16p12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1273h
Ensembl gene	ENSG00000274466
Ensembl biotype	miRNA
Entrez	102466247
RNAcentral	URS000075CB2D — ncRNA, 116 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612921

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612921 — 1 exons

Exon	Start	End
ENSE00003754356	24203116	24203231

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 77.06.

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.06	gold quality
monocyte	CL:0000576	75.98	gold quality
left coronary artery	UBERON:0001626	75.55	gold quality
gastrocnemius	UBERON:0001388	73.94	gold quality
bone marrow	UBERON:0002371	72.63	gold quality
left adrenal gland cortex	UBERON:0035825	71.01	gold quality
upper lobe of left lung	UBERON:0008952	69.82	gold quality
right lobe of liver	UBERON:0001114	69.60	gold quality
prefrontal cortex	UBERON:0000451	69.35	gold quality
tibial artery	UBERON:0007610	69.35	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.24	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.19	gold quality
hypothalamus	UBERON:0001898	69.02	gold quality
lung	UBERON:0002048	68.86	gold quality
ascending aorta	UBERON:0001496	68.81	gold quality
right atrium auricular region	UBERON:0006631	68.21	gold quality
right lung	UBERON:0002167	68.01	gold quality
skin of abdomen	UBERON:0001416	67.98	gold quality
lymph node	UBERON:0000029	67.76	gold quality
body of pancreas	UBERON:0001150	67.70	gold quality
body of stomach	UBERON:0001161	67.56	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.40	gold quality
urinary bladder	UBERON:0001255	67.08	gold quality
minor salivary gland	UBERON:0001830	67.08	gold quality
esophagus mucosa	UBERON:0002469	66.87	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.69	gold quality
vagina	UBERON:0000996	66.33	gold quality
transverse colon	UBERON:0001157	66.19	gold quality
omental fat pad	UBERON:0010414	66.08	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.