MIR1276

Summary

MIR1276 (microRNA 1276, HGNC:35347) is a microRNA gene on chromosome 15q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302121 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35347
Approved symbol	MIR1276
Name	microRNA 1276
Location	15q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1276
Ensembl gene	ENSG00000221634
Ensembl biotype	miRNA
Entrez	100302121
RNAcentral	URS0000759940 — miRNA, 83 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408707

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408707 — 1 exons

Exon	Start	End
ENSE00001565342	85770496	85770578

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 77.92.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	77.92	gold quality
prefrontal cortex	UBERON:0000451	75.62	gold quality
fundus of stomach	UBERON:0001160	75.10	gold quality
blood	UBERON:0000178	74.25	gold quality
muscle of leg	UBERON:0001383	73.83	gold quality
gastrocnemius	UBERON:0001388	73.19	gold quality
right coronary artery	UBERON:0001625	71.92	gold quality
descending thoracic aorta	UBERON:0002345	71.35	gold quality
stomach	UBERON:0000945	71.30	gold quality
lower esophagus mucosa	UBERON:0035834	71.25	gold quality
ectocervix	UBERON:0012249	71.07	gold quality
endometrium	UBERON:0001295	70.98	gold quality
liver	UBERON:0002107	70.96	gold quality
body of stomach	UBERON:0001161	70.82	gold quality
heart left ventricle	UBERON:0002084	70.68	gold quality
islet of Langerhans	UBERON:0000006	70.42	gold quality
heart	UBERON:0000948	70.32	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.23	gold quality
tibial artery	UBERON:0007610	69.89	gold quality
right atrium auricular region	UBERON:0006631	69.79	gold quality
myometrium	UBERON:0001296	69.65	gold quality
thoracic aorta	UBERON:0001515	68.88	gold quality
ascending aorta	UBERON:0001496	68.81	gold quality
body of pancreas	UBERON:0001150	68.50	gold quality
omental fat pad	UBERON:0010414	68.37	gold quality
lymph node	UBERON:0000029	68.14	gold quality
left coronary artery	UBERON:0001626	68.08	gold quality
skin of abdomen	UBERON:0001416	67.82	gold quality
right lobe of liver	UBERON:0001114	67.80	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.60

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• NF-kappaB promotes osteoclast differentiation by overexpressing MITF via down regulating microRNA-1276 expression. (PMID:32673666)
• Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR1276/SIRT4 axis. (PMID:34414449)
• Circ_0002623 promotes bladder cancer progression by regulating the miR-1276/SMAD2 axis. (PMID:35048477)
• CircTMEM87A promotes the tumorigenesis of gastric cancer by regulating the miR-1276/SLC7A11 axis. (PMID:38037531)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.