MIR1277

Summary

MIR1277 (microRNA 1277, HGNC:35350) is a microRNA gene on chromosome Xq24.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302214 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35350
Approved symbol	MIR1277
Name	microRNA 1277
Location	Xq24
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1277
Ensembl gene	ENSG00000221463
Ensembl biotype	miRNA
Entrez	100302214
RNAcentral	URS000075AF7D — miRNA, 78 nt, 13 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408536

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408536 — 1 exons

Exon	Start	End
ENSE00001565171	118386394	118386471

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 75.31.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	75.31	gold quality
blood	UBERON:0000178	74.78	gold quality
heart left ventricle	UBERON:0002084	74.07	gold quality
body of stomach	UBERON:0001161	69.85	gold quality
heart	UBERON:0000948	67.79	gold quality
ascending aorta	UBERON:0001496	66.78	gold quality
esophagus mucosa	UBERON:0002469	66.41	gold quality
tibial artery	UBERON:0007610	65.04	gold quality
intestine	UBERON:0000160	64.75	gold quality
left ovary	UBERON:0002119	62.82	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.52	gold quality
skin of leg	UBERON:0001511	61.96	gold quality
body of pancreas	UBERON:0001150	60.66	gold quality
right atrium auricular region	UBERON:0006631	60.32	gold quality
spleen	UBERON:0002106	57.96	gold quality
right hemisphere of cerebellum	UBERON:0014890	57.57	gold quality
colon	UBERON:0001155	56.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.91

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• XIST, matrix metalloproteinase 13 (MMP13) and ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5) were identified as targets of microRNA (miR)12775p, and the reciprocal inhibitive effect between XIST and miR12775p was elucidated. (PMID:31198977)
• Deficiency of NEAT1 prevented MPP(+)-induced inflammatory response, oxidative stress and apoptosis in dopaminergic SK-N-SH neuroblastoma cells via miR-1277-5p/ARHGAP26 axis. (PMID:33069733)
• Exosomal circ-BRWD1 contributes to osteoarthritis development through the modulation of miR-1277/TRAF6 axis. (PMID:34082824)
• LINC01123 promotes cell proliferation and migration via regulating miR-1277-5p/KLF5 axis in ox-LDL-induced vascular smooth muscle cells. (PMID:34403009)
• LINC01087 indicates a poor prognosis of glioma patients with preoperative MRI. (PMID:34817752)
• CircSMAD2 accelerates endometrial cancer cell proliferation and metastasis by regulating the miR-1277-5p/MFGE8 axis. (PMID:36659830)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.