MIR1278

Summary

MIR1278 (microRNA 1278, HGNC:35356) is a microRNA gene on chromosome 1q31.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302163 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35356
Approved symbol	MIR1278
Name	microRNA 1278
Location	1q31.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1278
Ensembl gene	ENSG00000221680
Ensembl biotype	miRNA
Entrez	100302163
RNAcentral	URS0000759994 — miRNA, 81 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408753

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408753 — 1 exons

Exon	Start	End
ENSE00001565388	193136503	193136583

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 85.15.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	85.15	gold quality
liver	UBERON:0002107	79.01	gold quality
bone marrow	UBERON:0002371	78.53	gold quality
blood	UBERON:0000178	76.62	gold quality
stomach	UBERON:0000945	75.47	gold quality
endometrium	UBERON:0001295	75.17	gold quality
adrenal tissue	UBERON:0018303	74.55	gold quality
calcaneal tendon	UBERON:0003701	74.11	gold quality
islet of Langerhans	UBERON:0000006	73.96	gold quality
substantia nigra	UBERON:0002038	73.04	gold quality
heart	UBERON:0000948	72.63	gold quality
gastrocnemius	UBERON:0001388	72.38	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.20	gold quality
Ammon’s horn	UBERON:0001954	70.81	gold quality
heart left ventricle	UBERON:0002084	69.26	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.69	gold quality
intestine	UBERON:0000160	68.52	gold quality
ascending aorta	UBERON:0001496	67.90	gold quality
body of stomach	UBERON:0001161	67.18	gold quality
tibial artery	UBERON:0007610	67.09	gold quality
anterior cingulate cortex	UBERON:0009835	66.45	gold quality
left adrenal gland	UBERON:0001234	66.27	gold quality
thoracic mammary gland	UBERON:0005200	66.22	gold quality
prostate gland	UBERON:0002367	65.96	gold quality
esophagus mucosa	UBERON:0002469	65.96	gold quality
colon	UBERON:0001155	65.95	gold quality
right atrium auricular region	UBERON:0006631	65.11	gold quality
skin of leg	UBERON:0001511	64.53	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.51	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• miR-1278 sensitizes nasopharyngeal carcinoma cells to cisplatin and suppresses autophagy via targeting ATG2B. (PMID:32407879)
• LINC00294 negatively modulates cell proliferation in glioma through a neurofilament medium-mediated pathway via interacting with miR-1278. (PMID:32450002)
• Circular RNA-0007059 protects cell viability and reduces inflammation in a nephritis cell model by inhibiting microRNA-1278/SHP-1/STAT3 signaling. (PMID:34535085)
• Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis. (PMID:36738165)
• circPKD2 inhibits the glioma cell proliferation, invasion and glycolytic metabolism through regulating the miR-1278/LATS2 axis. (PMID:36796622)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.