MIR128-1

Summary

MIR128-1 (microRNA 128-1, HGNC:31510) is a microRNA gene on chromosome 2q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406915 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31510
Approved symbol	MIR128-1
Name	microRNA 128-1
Location	2q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-128a, hsa-mir-128-1, mir-128-1
Ensembl gene	ENSG00000207654
Ensembl biotype	miRNA
OMIM	611774
Entrez	406915
RNAcentral	URS00002D9CBA — miRNA, 82 nt, 29 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384921

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384921 — 1 exons

Exon	Start	End
ENSE00001499928	135665397	135665478

Expression profiles

Bgee: expression breadth broad, 72 present calls, max score 82.73.

Top tissues by expression

72 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	82.73	gold quality
monocyte	CL:0000576	79.18	gold quality
blood	UBERON:0000178	76.44	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.86	gold quality
islet of Langerhans	UBERON:0000006	73.78	gold quality
gastrocnemius	UBERON:0001388	73.62	gold quality
heart	UBERON:0000948	73.22	gold quality
endometrium	UBERON:0001295	72.05	gold quality
tibial artery	UBERON:0007610	71.11	gold quality
adult mammalian kidney	UBERON:0000082	70.94	gold quality
lung	UBERON:0002048	70.33	gold quality
popliteal artery	UBERON:0002250	70.24	gold quality
stomach	UBERON:0000945	69.51	gold quality
prefrontal cortex	UBERON:0000451	68.47	gold quality
liver	UBERON:0002107	68.31	gold quality
granulocyte	CL:0000094	68.16	gold quality
body of stomach	UBERON:0001161	67.37	gold quality
lymph node	UBERON:0000029	67.11	gold quality
left adrenal gland	UBERON:0001234	67.03	gold quality
right atrium auricular region	UBERON:0006631	66.85	gold quality
caudate nucleus	UBERON:0001873	66.35	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.21	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.03	gold quality
tonsil	UBERON:0002372	65.96	gold quality
ascending aorta	UBERON:0001496	65.85	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.68	gold quality
left coronary artery	UBERON:0001626	65.49	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.28	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.77	gold quality
esophagus mucosa	UBERON:0002469	64.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• findings show HIV-1 Tat deregulates expression levels of microRNAs, including mir-128, in cortical neurons; mir-128a inhibits expression of SNAP25; the anti-mir-128a partially restores Tat/mir-128a-induced downregulation of SNAP25 expression (PMID:18381601)
• a role for miR-128 in the molecular events modulating neuroblastoma progression and aggressiveness (PMID:19713529)
• miR-128 is a potentially important negative regulator of prostate cancer cell invasion. (PMID:19955085)
• Data suggest that the hormone-responsive miR-128a can modulate TGFbeta signaling and survival of the letrozole-resistant breast cancer cell lines. (PMID:20054641)
• Data show there was an inverse correlation between the expression level of EZH2 and that of miR-101 or miR-128a, suggesting that the altered expression of the latter miRNAs accounts for the overexpression of the former. (PMID:21228036)
• The over-expression of the naturally under-expressed miR-128 in glioma cells resulted in the inhibition of WEE1 in glioblastoma cells. (PMID:21358821)
• miR-128-1 represses nonsense-mediated RNA decay by targeting the RNA helicase UPF1 and the exon-junction complex core component MLN51. (PMID:21596314)
• miR-26b and miR-128 as central regulators of pituitary somatomammotrophic tumor growth through activation of the PTEN-AKT pathway. (PMID:22614013)
• MiR-7 transfection into ovarian cancer cells induces changes in cell adhesion and other developmental networks, while miR-128 transfection induces changes in cell cycle control. (PMID:22853714)
• Low miR-128 is associated with glioblastoma. (PMID:23482671)
• MiR-128 exerts pro-apoptotic effect in a p53 transcription-dependent and -independent manner via PUMA-Bak axis. (PMID:23492773)
• Reduced expression of miR-128 is associated with glioma. (PMID:23835497)
• Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. (PMID:23958464)
• Low microRNA-128 expression is associated with colorectal cancer. (PMID:24046120)
• miR-128 inhibition in monocytes from AD patients improves Ab(1-42) degradation. These results could contribute to clarify the molecular mechanisms that affect the imbalanced Ab production/clearance involved in the pathogenesis of AD. (PMID:24064186)
• CH-11 induced demethylation of the promoter region of miR-128a. (PMID:24316133)
• The secreted proteins from Salmonella were identified as possible effectors to induce miR-128 expression via the p53 signaling pathway. (PMID:24415783)
• MIR128a and MIR146a SNPs are associated with diabetic polyneuropathy susceptibility. (PMID:24682535)
• low expression of miR-124-3p, miR-128-1, and miR-221-3p may constitute a potential marker of astrocytomas that correlates with localization (PMID:24718706)
• Overexpression of miR-128 increased programmed cell death but had no effect on cell cycle profile (PMID:24846063)
• Data revealed that upregulated SNAI1 accelerates glioma progression and suppresses the expression of miR-128, which can oppose SNAI1’s effect and modulate SP1 expression. (PMID:24959930)
• Study showed that the expression of miR-128 and miR-149 was downregulated in glioblastoma; the lower expression of miR-128 and miR-149 contributed to astrocytoma tumorigenesis. (PMID:25017996)
• miR-128 may act as a promising therapeutic target for improvement of tumor sensitivity to cisplatin. (PMID:25248111)
• the expression of hsa-miR-128-3p is inversely correlated with the expression of CYP2C9 in hepatocellular carcinoma tumor tissues; the study helped to elucidate the mechanism of CYP2C9 regulation by hsa-miR-128-3p, and the inverse association in hepatocellular carcinoma (PMID:25704921)
• Data suggest that miR-128 acted as a tumor suppressor inhibiting the head and neck squamous cell carcinoma growth by directly mediating the expression of putative targets. (PMID:25764126)
• Data indicate that plentiful targets of microRNA miR-128 were screened and laid the foundation for research into the miR-128 regulation network. (PMID:25781272)
• The use of miR-128 as a diagnostic and/or therapeutic tool may result in improvements in diagnosis, prognosis, and treatment of numerous cancers. (PMID:25916109)
• miR-128 functions as a tumor suppressor by directly targeting ZEB1 in prostate cancer. (PMID:25921099)
• we conclude that miR-128-3p, which is frequently downregulated in HCC, inhibits hepatocellular carcinoma (HCC). progression by regulating PIK3R1 and PI3K/AKT activation, and is a prognostic marker for HCC patients. (PMID:25962360)
• miRNA-128a and its downstream target gene Bmi-1 may have an important role in the radioresistance of U-87 MG glioma cells. (PMID:26238021)
• Levels of miR-128 are decreased in astrocytoma tumor cell lines compared to normal astrocytes. (PMID:26307612)
• Mutant IDH1 R132H decreased cell proliferation of U87 glioma cells by inducing the expression of the miRNA miR128a. (PMID:26324126)
• Decreased expression of miR-128 in both tissue and serum samples of prostate cancer patients may be associated with tumor malignant progression and BCR-free survival. (PMID:26339409)
• miR-128 represses L1 retrotransposition by binding directly to L1 RNA. (PMID:26367248)
• miR-27b, miR-101 and miR-128 inhibit angiogenesis by down-regulating VEGF-C expression in gastric cancers. (PMID:26460960)
• high miR-128 expression suppressed osteosarcoma cell migration, invasion, and EMT development through targeting ITGA2, which may be recommended as a therapeutic target for osteosarcoma (PMID:26700675)
• miR-128 regulates the differentiation of human hair follicle mesenchymal stem cells into smooth muscle cells via targeting SMAD2, a main transcription regulator in TGF-beta signaling pathway involving smooth muscle cell differentiation. (PMID:27087048)
• miR-128 and miR-125 could help to increase the nonsense-mutant F9 levels by repressing nonsense-mediated mRNA decay. (PMID:27133073)
• miR-128a is an up-regulated miRNA in patient with preeclampsia. (PMID:27261578)
• AurkA suppresses the expression of miR-128, inhibitor of wnt3a mRNA stabilization. (PMID:27341528)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir128-2	ENSDARG00000083495
mus_musculus	Mir128-1	ENSMUSG00000065520
rattus_norvegicus	Mir128-1	ENSRNOG00000035534

Paralogs (1): MIR128-2 (ENSG00000207625)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.