MIR1281

Summary

MIR1281 (microRNA 1281, HGNC:35359) is a microRNA gene on chromosome 22q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302237 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35359
Approved symbol	MIR1281
Name	microRNA 1281
Location	22q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1281
Ensembl gene	ENSG00000284015
Ensembl biotype	miRNA
Entrez	100302237
RNAcentral	URS000075DF7B — miRNA, 54 nt, 11 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408233

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408233 — 1 exons

Exon	Start	End
ENSE00001564868	41092513	41092566

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 99.26.

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.26	gold quality
skeletal muscle tissue	UBERON:0001134	94.65	gold quality
adrenal tissue	UBERON:0018303	94.31	gold quality
vermiform appendix	UBERON:0001154	88.80	gold quality
duodenum	UBERON:0002114	85.30	gold quality
bone marrow	UBERON:0002371	84.25	gold quality
blood	UBERON:0000178	83.80	gold quality
monocyte	CL:0000576	81.73	gold quality
prefrontal cortex	UBERON:0000451	81.32	gold quality
liver	UBERON:0002107	81.27	gold quality
lymph node	UBERON:0000029	79.83	gold quality
muscle of leg	UBERON:0001383	79.54	gold quality
granulocyte	CL:0000094	79.30	gold quality
smooth muscle tissue	UBERON:0001135	79.26	gold quality
placenta	UBERON:0001987	78.86	gold quality
gastrocnemius	UBERON:0001388	78.39	gold quality
calcaneal tendon	UBERON:0003701	78.14	gold quality
islet of Langerhans	UBERON:0000006	76.36	gold quality
endometrium	UBERON:0001295	76.31	gold quality
stomach	UBERON:0000945	76.17	gold quality
kidney	UBERON:0002113	75.90	gold quality
lung	UBERON:0002048	75.85	gold quality
adult mammalian kidney	UBERON:0000082	75.84	gold quality
heart left ventricle	UBERON:0002084	75.39	gold quality
heart	UBERON:0000948	75.36	gold quality
popliteal artery	UBERON:0002250	74.08	gold quality
tibial artery	UBERON:0007610	74.03	gold quality
pancreas	UBERON:0001264	73.99	gold quality
right atrium auricular region	UBERON:0006631	73.82	gold quality
lower esophagus muscularis layer	UBERON:0035833	73.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Data suggest that three microRNAs (miR-191-3p, miR-455-3p, and miR-1281) are up-regulated in plasma of patients with abdominal aortic aneurysms as compared to control subjects; thus, these microRNAs are potential plasma biomarkers. (PMID:25916817)
• Three circulating up-regulated microRNAs, miR-197-3p, miR-1281 and miR-32-3p, are proposed as potential new malignant pleural mesothelioma biomarkers. (PMID:27716620)
• High MIR1281 expression is associated with oropharyngeal cancer metastasis. (PMID:29663357)
• this study first demonstrated that a novel LINC01857/miR-1281/TRIM65 signaling regulates glioma progression (PMID:31049960)
• LncRNA GIHCG regulates microRNA-1281 and promotes malignant progression of breast cancer. (PMID:31858553)
• Targeting cyclophilin-D by miR-1281 protects human macrophages from Mycobacterium tuberculosis-induced programmed necrosis and apoptosis. (PMID:31884421)
• MicroRNA-1281 as a Novel Circulating Biomarker in Patients With Diabetic Retinopathy. (PMID:32849308)
• LncRNA LINC00963 promotes colorectal cancer cell proliferation and metastasis by regulating miR1281 and TRIM65. (PMID:34498706)
• Circ_0001588 Upregulates ERBB4 to Promote Glioma Malignant Progression Through Sponging miR-1281. (PMID:34982356)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.