MIR1282

Summary

MIR1282 (microRNA 1282, HGNC:35360) is a microRNA gene on chromosome 15q15.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302254 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35360
Approved symbol	MIR1282
Name	microRNA 1282
Location	15q15.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1282
Ensembl gene	ENSG00000221792
Ensembl biotype	miRNA
Entrez	100302254
RNAcentral	URS000075D475 — miRNA, 101 nt, 71 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408865

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408865 — 1 exons

Exon	Start	End
ENSE00001565500	43793659	43793759

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 95.33.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.33	gold quality
tibial nerve	UBERON:0001323	91.60	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	90.67	gold quality
gastrocnemius	UBERON:0001388	87.02	gold quality
blood	UBERON:0000178	86.58	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	83.61	gold quality
muscle of leg	UBERON:0001383	78.11	gold quality
calcaneal tendon	UBERON:0003701	75.54	gold quality
heart	UBERON:0000948	74.27	gold quality
upper lobe of left lung	UBERON:0008952	72.29	gold quality
heart left ventricle	UBERON:0002084	71.42	gold quality
left lobe of thyroid gland	UBERON:0001120	70.00	gold quality
putamen	UBERON:0001874	66.95	gold quality
caudate nucleus	UBERON:0001873	66.73	gold quality
islet of Langerhans	UBERON:0000006	64.72	gold quality
adrenal gland	UBERON:0002369	62.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm22953	ENSMUSG00000080374

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.