MIR1283-1

Summary

MIR1283-1 (microRNA 1283-1, HGNC:35255) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302265 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35255
Approved symbol	MIR1283-1
Name	microRNA 1283-1
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1283-1
Ensembl gene	ENSG00000221421
Ensembl biotype	miRNA
OMIM	620644
Entrez	100302265
RNAcentral	URS000075C919 — miRNA, 87 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408494

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408494 — 1 exons

Exon	Start	End
ENSE00001807918	53688481	53688567

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 65.33.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
fundus of stomach	UBERON:0001160	65.33	gold quality
ascending aorta	UBERON:0001496	64.75	gold quality
skin of abdomen	UBERON:0001416	64.16	gold quality
myometrium	UBERON:0001296	63.89	gold quality
vagina	UBERON:0000996	63.84	gold quality
urinary bladder	UBERON:0001255	63.25	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.96	gold quality
left testis	UBERON:0004533	45.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• genetic association studies in a population in China: Data suggest that an SNP in ATF1 (rs11169571) is associated with essential hypertension in the population studied; altered binding of microRNA-1283 appears to be involved. (PMID:26149214)
• regulates the PERK/ATF4 pathway in vascular injury by targeting ATF4 (PMID:27537404)
• Dysregulation in the expression of (lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283) in spinal cord injury. (PMID:32535070)
• MicroRNA 1283 alleviates cardiomyocyte damage caused by hypoxia /reoxygenation via targeting GADD45A and inactivating the JNK and p38 MAPK signaling pathways. (PMID:33293495)
• miR-1283 Contributes to Endoplasmic Reticulum Stress in the Development of Hypertension Through the Activating Transcription Factor-4 (ATF4)/C/EBP-Homologous Protein (CHOP) Signaling Pathway. (PMID:33911065)
• KLF14/miR-1283/TFAP2C axis inhibits HER2-positive breast cancer progression via declining tumor cell proliferation. (PMID:36752341)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.