MIR1283-2

Summary

MIR1283-2 (microRNA 1283-2, HGNC:35361) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302205 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35361
Approved symbol	MIR1283-2
Name	microRNA 1283-2
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1283-2
Ensembl gene	ENSG00000221548
Ensembl biotype	miRNA
OMIM	620645
Entrez	100302205
RNAcentral	URS000075BC4A — miRNA, 87 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408621

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408621 — 1 exons

Exon	Start	End
ENSE00001806883	53758232	53758318

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 80.76.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.76	gold quality
gastrocnemius	UBERON:0001388	77.82	gold quality
placenta	UBERON:0001987	76.77	gold quality
monocyte	CL:0000576	72.04	gold quality
esophagus mucosa	UBERON:0002469	69.69	gold quality
body of pancreas	UBERON:0001150	68.86	gold quality
vagina	UBERON:0000996	67.39	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.22	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.05	gold quality
skin of abdomen	UBERON:0001416	65.41	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.43	gold quality
body of uterus	UBERON:0009853	63.83	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.66	gold quality
endocervix	UBERON:0000458	63.59	gold quality
body of stomach	UBERON:0001161	62.92	gold quality
ectocervix	UBERON:0012249	61.59	gold quality
upper lobe of left lung	UBERON:0008952	60.34	gold quality
tibial nerve	UBERON:0001323	58.52	gold quality
prostate gland	UBERON:0002367	57.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• regulates the PERK/ATF4 pathway in vascular injury by targeting ATF4 (PMID:27537404)
• Dysregulation in the expression of (lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283) in spinal cord injury. (PMID:32535070)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.