MIR1284

Summary

MIR1284 (microRNA 1284, HGNC:35362) is a microRNA gene on chromosome 3p13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302112 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35362
Approved symbol	MIR1284
Name	microRNA 1284
Location	3p13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1284
Ensembl gene	ENSG00000221264
Ensembl biotype	miRNA
Entrez	100302112
RNAcentral	URS000075AFA3 — miRNA, 120 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408337

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408337 — 1 exons

Exon	Start	End
ENSE00001564972	71541970	71542089

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 77.77.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	77.77	gold quality
monocyte	CL:0000576	77.66	gold quality
anterior cingulate cortex	UBERON:0009835	77.50	gold quality
blood	UBERON:0000178	76.89	gold quality
calcaneal tendon	UBERON:0003701	76.80	gold quality
adult mammalian kidney	UBERON:0000082	76.55	gold quality
myometrium	UBERON:0001296	76.12	gold quality
kidney	UBERON:0002113	75.94	gold quality
stomach	UBERON:0000945	75.22	gold quality
bone marrow	UBERON:0002371	73.95	gold quality
corpus callosum	UBERON:0002336	73.50	gold quality
descending thoracic aorta	UBERON:0002345	72.71	gold quality
islet of Langerhans	UBERON:0000006	72.43	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.74	gold quality
Ammon’s horn	UBERON:0001954	71.72	gold quality
endometrium	UBERON:0001295	71.53	gold quality
body of pancreas	UBERON:0001150	71.17	gold quality
gastrocnemius	UBERON:0001388	71.05	gold quality
body of stomach	UBERON:0001161	70.61	gold quality
tibial artery	UBERON:0007610	70.16	gold quality
lung	UBERON:0002048	69.27	gold quality
urinary bladder	UBERON:0001255	69.21	gold quality
thoracic aorta	UBERON:0001515	69.10	gold quality
ascending aorta	UBERON:0001496	68.98	gold quality
vagina	UBERON:0000996	68.83	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.71	gold quality
colon	UBERON:0001155	68.16	gold quality
intestine	UBERON:0000160	68.13	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.98	gold quality
heart	UBERON:0000948	67.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• miR-1284 can function as a new regulator to reduce gastric cancer multidrug resistant cells by targeting EIF4A1. (PMID:26936591)
• miR1284 affects cell proliferation and apoptosis of lung cancer cells. (PMID:28713980)
• The overexpression of miR-1284 inhibited the cell proliferation and migration, and altered the protein expression of epithelial-mesenchymal transition (EMT)-associated genes (E-cadherin, N-cadherin, Vimentin, and Snail), which was reversed by HMGB1 overexpression. In conclusion, miR-1284 can function as a new regulator to inhibit osteosarcoma cell proliferation and migration by targeting HMGB1. (PMID:29899164)
• miR-1284 suppressed the proliferation, migration, and invasion of breast cancer cells via targeting ZIC2. (PMID:30075825)
• miR-1284 enhances sensitivity of cervical cancer cells to cisplatin via targeting HMGB1; patients with low level of miR-1284 had low overall survival rate (PMID:30257412)
• MiR-1284 suppresses the proliferation and migration of thyroid cancer. (PMID:37715373)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.