MIR1285-2

Summary

MIR1285-2 (microRNA 1285-2, HGNC:35278) is a microRNA gene on chromosome 2p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302268 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35278
Approved symbol	MIR1285-2
Name	microRNA 1285-2
Location	2p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1285-2
Ensembl gene	ENSG00000221238
Ensembl biotype	miRNA
Entrez	100302268
RNAcentral	URS000075A68E — miRNA, 88 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408311

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408311 — 1 exons

Exon	Start	End
ENSE00001808008	70252918	70253005

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 74.81.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	74.81	gold quality
gastrocnemius	UBERON:0001388	72.54	gold quality
monocyte	CL:0000576	71.97	gold quality
right atrium auricular region	UBERON:0006631	71.66	gold quality
endometrium	UBERON:0001295	71.24	gold quality
body of pancreas	UBERON:0001150	71.13	gold quality
nucleus accumbens	UBERON:0001882	70.62	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.31	gold quality
hypothalamus	UBERON:0001898	69.81	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.81	gold quality
heart left ventricle	UBERON:0002084	69.48	gold quality
right lobe of liver	UBERON:0001114	69.42	gold quality
transverse colon	UBERON:0001157	67.26	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.20	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.93	gold quality
ascending aorta	UBERON:0001496	66.77	gold quality
left coronary artery	UBERON:0001626	66.17	gold quality
skin of abdomen	UBERON:0001416	65.33	gold quality
left ovary	UBERON:0002119	65.14	gold quality
colon	UBERON:0001155	64.94	gold quality
multicellular organism	UBERON:0000468	64.69	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.39	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.10	gold quality
cerebellar hemisphere	UBERON:0002245	64.03	gold quality
substantia nigra	UBERON:0002038	63.89	gold quality
liver	UBERON:0002107	63.84	gold quality
caudate nucleus	UBERON:0001873	63.82	gold quality
minor salivary gland	UBERON:0001830	63.79	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.73	gold quality
skin of leg	UBERON:0001511	63.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• The combination of plasma miR-324-3p and miR-1285 could further improve the diagnostic accuracy of lung squamous cell carcinoma (LSCC). (PMID:27517633)
• miR-1285 suppressed cell proliferation as well as increased the sensitivity of pancreatic ductal adenocarcinoma cells to gemcitabine; miR-1285 inhibited pancreatic cancer cell migration and invasion (PMID:28253715)
• Methylation dependent microRNA 1285-5p and sterol carrier proteins 2 in type 2 diabetes mellitus (PMID:31407919)
• Data showed the tumor-suppressive role of miR-1285 and detailed its mechanism of action in breast cancer. Its overexpression significantly inhibited cell proliferation in breast cancer cells regardless of the tumor subtype. Also, miR-1285 was found to regulate TMEM194A expression by binding to its 3’-UTR. (PMID:31854049)
• Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p. (PMID:32462972)
• Repression of Smad4 by MicroRNA-1285 moderates TGF-beta-induced epithelial-mesenchymal transition in proliferative vitreoretinopathy. (PMID:34383767)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.