MIR1286

Summary

MIR1286 (microRNA 1286, HGNC:35279) is a microRNA gene on chromosome 22q11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302118 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35279
Approved symbol	MIR1286
Name	microRNA 1286
Location	22q11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1286
Ensembl gene	ENSG00000221039
Ensembl biotype	miRNA
Entrez	100302118
RNAcentral	URS000075C8A9 — miRNA, 78 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408112

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408112 — 1 exons

Exon	Start	End
ENSE00001564747	20249134	20249211

Expression profiles

Bgee: expression breadth broad, 72 present calls, max score 83.48.

Top tissues by expression

72 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	83.48	gold quality
right hemisphere of cerebellum	UBERON:0014890	82.48	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.13	gold quality
adult mammalian kidney	UBERON:0000082	80.92	gold quality
prefrontal cortex	UBERON:0000451	80.91	gold quality
cerebellar hemisphere	UBERON:0002245	79.83	gold quality
endometrium	UBERON:0001295	75.97	gold quality
blood	UBERON:0000178	74.71	gold quality
brain	UBERON:0000955	71.35	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.86	gold quality
liver	UBERON:0002107	70.41	gold quality
right lobe of liver	UBERON:0001114	69.44	gold quality
body of stomach	UBERON:0001161	69.34	gold quality
gastrocnemius	UBERON:0001388	69.31	gold quality
frontal cortex	UBERON:0001870	69.04	gold quality
stomach	UBERON:0000945	68.78	gold quality
body of pancreas	UBERON:0001150	68.54	gold quality
right frontal lobe	UBERON:0002810	68.40	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.40	gold quality
heart left ventricle	UBERON:0002084	68.30	gold quality
lymph node	UBERON:0000029	67.99	gold quality
heart	UBERON:0000948	67.79	gold quality
left adrenal gland cortex	UBERON:0035825	67.11	gold quality
granulocyte	CL:0000094	67.05	gold quality
descending thoracic aorta	UBERON:0002345	66.94	gold quality
amygdala	UBERON:0001876	66.77	gold quality
tibial artery	UBERON:0007610	66.58	gold quality
ascending aorta	UBERON:0001496	66.44	gold quality
anterior cingulate cortex	UBERON:0009835	66.38	gold quality
skin of leg	UBERON:0001511	66.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• MicroRNA-1286 inhibits osteogenic differentiation of mesenchymal stem cells to promote the progression of osteoporosis via regulating FZD4 expression. (PMID:31957812)
• CircCOL1A2 Sponges MiR-1286 to Promote Cell Invasion and Migration of Gastric Cancer by Elevating Expression of USP10 to Downregulate RFC2 Ubiquitination Level. (PMID:35791074)
• Circ_0051079 functions as an oncogenic regulator in osteosarcoma by leading to MAFB expression upregulation by competitively interacting with miR-1286. (PMID:36153605)
• Long non-coding HOXA-AS3 contributes to osteosarcoma progression through the miR-1286/TEAD1 axis. (PMID:37752588)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.