MIR1287

Summary

MIR1287 (microRNA 1287, HGNC:35280) is a microRNA gene on chromosome 10q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302133 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35280
Approved symbol	MIR1287
Name	microRNA 1287
Location	10q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1287
Ensembl gene	ENSG00000284415
Ensembl biotype	miRNA
Entrez	100302133
RNAcentral	URS000072632B — miRNA, 90 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408492

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408492 — 1 exons

Exon	Start	End
ENSE00001565127	98395218	98395307

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 91.36.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	91.36	gold quality
bone marrow	UBERON:0002371	78.48	gold quality
urinary bladder	UBERON:0001255	74.82	gold quality
placenta	UBERON:0001987	74.36	gold quality
blood	UBERON:0000178	73.39	gold quality
muscle of leg	UBERON:0001383	73.25	gold quality
skeletal muscle tissue	UBERON:0001134	72.58	gold quality
islet of Langerhans	UBERON:0000006	72.45	gold quality
right atrium auricular region	UBERON:0006631	71.69	gold quality
gastrocnemius	UBERON:0001388	71.62	gold quality
lymph node	UBERON:0000029	70.92	gold quality
heart	UBERON:0000948	70.59	gold quality
heart left ventricle	UBERON:0002084	70.32	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.28	gold quality
body of stomach	UBERON:0001161	70.10	gold quality
stomach	UBERON:0000945	69.92	gold quality
right adrenal gland	UBERON:0001233	69.61	gold quality
ectocervix	UBERON:0012249	69.59	gold quality
body of pancreas	UBERON:0001150	69.26	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.09	gold quality
right ovary	UBERON:0002118	69.03	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.98	gold quality
lower esophagus	UBERON:0013473	68.88	gold quality
endometrium	UBERON:0001295	68.74	gold quality
left adrenal gland	UBERON:0001234	68.59	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.44	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.21	gold quality
Ammon’s horn	UBERON:0001954	68.15	gold quality
tibial artery	UBERON:0007610	68.02	gold quality
anterior cingulate cortex	UBERON:0009835	67.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 21)

• Data indicate that the hsa-miR-657-hsa-miR-1287 classifier displayed high sensitivity and specificity for discriminating between early larynx carcinoma and normal mucosa tissues. (PMID:24238754)
• MiR-1287 was significantly upregulated in the group of CRC samples compared with matched noncancerous tissue samples. (PMID:27251300)
• The circ_0016760/miR-1287/GAGE1 signaling might play vital roles in the tumorigenesis and progression of Non-small cell lung cancer (NSCLC). (PMID:30103946)
• miR-1287-5p was significantly downregulated in mammospheres and human breast cancer (BC) tissue compared to normal breast tissue and was associated with poor prognosis in BC patients. MiR-1287-5p significantly decreased cellular growth, cells in S phase of cell cycle, and tumor formation in vivo. PIK3CB was identified as a direct molecular interactor of miR-1287-5p and a novel prognostic factor in BC. (PMID:30709367)
• Circular RNA hsa_circ_0004812 impairs IFN-induced immune response by sponging miR-1287-5p to regulate FSTL1 in chronic hepatitis B. (PMID:32188476)
• Circ_0075829 facilitates the progression of pancreatic carcinoma by sponging miR-1287-5p and activating LAMTOR3 signalling. (PMID:33184989)
• Hsa_circ_0099198 facilitates the progression of retinoblastoma by regulating miR-1287/LRP6 axis. (PMID:33676964)
• Circular RNA circCCT3 promotes hepatocellular carcinoma progression by regulating the miR12875p/TEAD1/PTCH1/LOX axis. (PMID:33760147)
• Hsa_circ_0001982 promotes the progression of breast cancer through miR-1287-5p/MUC19 axis under hypoxia. (PMID:34082777)
• miR-1287-5p upregulation inhibits the EMT and pro-inflammatory cytokines in LPS-induced human nasal epithelial cells (HNECs). (PMID:34139308)
• MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4. (PMID:35038953)
• Exosomal circ_0048856 derived from non-small cell lung cancer contributes to aggressive cancer progression through downregulation of miR-1287-5p. (PMID:35228162)
• Circ_0075804 Regulates the Expression of LASP1 by Targeting miR-1287-5p and Thus Affects the Biological Process of Retinoblastoma. (PMID:35285372)
• Cancer-released exosomal circular RNA circ_0008717 promotes cell tumorigenicity through microRNA-1287-5p/P21-activated kinase 2 (PAK2) axis in non-small cell lung cancer. (PMID:35333693)
• The Down-Regulation of Circ_0059707 in Acute Myeloid Leukemia Promotes Cell Growth and Inhibits Apoptosis by Regulating miR-1287-5p. (PMID:36135094)
• Microscopic polyangiitis plasma-derived exosomal miR-1287-5p induces endothelial inflammatory injury and neutrophil adhesion by targeting CBL. (PMID:36726727)
• Downregulation of circ_PLXND1 inhibits tumorigenesis of non-small cell lung carcinoma via miR-1287-5p/ERBB3 axis. (PMID:37073425)
• Circ_0002295 facilitated myocardial fibrosis progression through the miR-1287/CXCR2 axis. (PMID:37688444)
• CircPI4KA Overexpression Enhances Carcinogenesis and Glycolysis Metabolism in Papillary Thyroid Carcinoma by Causing the miR-1287-5p-Mediated NRP2 Expression Elevation. (PMID:37813099)
• Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis. (PMID:38539084)
• CircCOL5A1 is involved in proliferation, invasion, and inhibition of ferroptosis of colorectal cancer cells via miR-1287-5p/SLC7A11. (PMID:39030862)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.