MIR1288

Summary

MIR1288 (microRNA 1288, HGNC:35363) is a microRNA gene on chromosome 17p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302124 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35363
Approved symbol	MIR1288
Name	microRNA 1288
Location	17p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1288
Ensembl gene	ENSG00000221355
Ensembl biotype	miRNA
Entrez	100302124
RNAcentral	URS000075C2CE — miRNA, 75 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408428

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408428 — 1 exons

Exon	Start	End
ENSE00001565063	16282014	16282088

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 79.69.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	79.69	gold quality
blood	UBERON:0000178	78.00	gold quality
adrenal tissue	UBERON:0018303	77.11	gold quality
kidney	UBERON:0002113	76.80	gold quality
gastrocnemius	UBERON:0001388	72.89	gold quality
liver	UBERON:0002107	72.16	gold quality
stomach	UBERON:0000945	71.13	gold quality
amygdala	UBERON:0001876	70.76	gold quality
adult mammalian kidney	UBERON:0000082	69.64	gold quality
left adrenal gland	UBERON:0001234	68.26	gold quality
body of stomach	UBERON:0001161	67.60	gold quality
lung	UBERON:0002048	67.44	gold quality
heart	UBERON:0000948	67.42	gold quality
tibial artery	UBERON:0007610	67.36	gold quality
endometrium	UBERON:0001295	67.24	gold quality
right frontal lobe	UBERON:0002810	66.93	gold quality
intestine	UBERON:0000160	66.55	gold quality
vagina	UBERON:0000996	66.34	gold quality
ascending aorta	UBERON:0001496	65.93	gold quality
omental fat pad	UBERON:0010414	65.91	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.86	gold quality
right lobe of liver	UBERON:0001114	65.85	gold quality
right atrium auricular region	UBERON:0006631	65.19	gold quality
colon	UBERON:0001155	65.10	gold quality
esophagus mucosa	UBERON:0002469	65.08	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.97	gold quality
skin of abdomen	UBERON:0001416	64.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.39	gold quality
myometrium	UBERON:0001296	64.24	gold quality
left adrenal gland cortex	UBERON:0035825	64.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Reduced expression of miR-1288 is associated with colorectal cancer. (PMID:24009195)
• Overexpression of miR-1288 play a key role in the pathogenesis of oesophageal squamous cell carcinoma. (PMID:27658568)
• Ectopic expression of miR1288 promoted the prolife-ration, colony formation and anchorageindependent growth of GBM cells and miR1288 promoted cell proliferation of GBM by targeting ubiquitin carboxylterminal hydrolase (CYLD). (PMID:28901464)
• the minor allele C of rs7219 is identified as a risk allele for Schizophrenia (SCZ) because it generates a binding site for miR-1288, thereby resulting in decreased expression of GRB2 and ultimately increasing the risk of SCZ. (PMID:30474799)
• Negative regulation of miR-1288-3p/KRT4 axis through a circular RNA in oral cancer. (PMID:35707935)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.