MIR1289-1

Summary

MIR1289-1 (microRNA 1289-1, HGNC:35281) is a microRNA gene on chromosome 20q11.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302125 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35281
Approved symbol	MIR1289-1
Name	microRNA 1289-1
Location	20q11.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1289-1
Ensembl gene	ENSG00000221763
Ensembl biotype	miRNA
Entrez	100302125
RNAcentral	URS000075D83B — miRNA, 144 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408836

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408836 — 1 exons

Exon	Start	End
ENSE00001565471	35453954	35454097

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 75.81.

Top tissues by expression

85 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	75.81	gold quality
monocyte	CL:0000576	73.16	gold quality
fundus of stomach	UBERON:0001160	72.17	gold quality
blood	UBERON:0000178	71.44	gold quality
muscle of leg	UBERON:0001383	70.79	gold quality
islet of Langerhans	UBERON:0000006	70.37	gold quality
right uterine tube	UBERON:0001302	70.29	gold quality
corpus callosum	UBERON:0002336	70.21	gold quality
gastrocnemius	UBERON:0001388	69.35	gold quality
tibial artery	UBERON:0007610	69.34	gold quality
body of pancreas	UBERON:0001150	68.91	gold quality
adrenal tissue	UBERON:0018303	66.60	gold quality
rectum	UBERON:0001052	66.34	gold quality
prefrontal cortex	UBERON:0000451	66.13	gold quality
heart left ventricle	UBERON:0002084	65.55	gold quality
heart	UBERON:0000948	65.52	gold quality
upper lobe of left lung	UBERON:0008952	64.46	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.31	gold quality
myometrium	UBERON:0001296	64.24	gold quality
urinary bladder	UBERON:0001255	64.21	gold quality
left adrenal gland cortex	UBERON:0035825	63.90	gold quality
stomach	UBERON:0000945	63.76	gold quality
ovary	UBERON:0000992	63.75	gold quality
left ovary	UBERON:0002119	63.75	gold quality
omental fat pad	UBERON:0010414	63.64	gold quality
ascending aorta	UBERON:0001496	63.36	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.26	gold quality
thoracic aorta	UBERON:0001515	63.06	gold quality
esophagus mucosa	UBERON:0002469	63.06	gold quality
endometrium	UBERON:0001295	63.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.