MIR1289-2

Summary

MIR1289-2 (microRNA 1289-2, HGNC:35282) is a microRNA gene on chromosome 5q31.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302134 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35282
Approved symbol	MIR1289-2
Name	microRNA 1289-2
Location	5q31.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1289-2
Ensembl gene	ENSG00000221287
Ensembl biotype	miRNA
Entrez	100302134
RNAcentral	URS000075B3E2 — miRNA, 111 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408360

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408360 — 1 exons

Exon	Start	End
ENSE00001564995	133427596	133427706

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 76.18.

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	76.18	gold quality
stomach	UBERON:0000945	73.67	gold quality
corpus callosum	UBERON:0002336	71.94	gold quality
substantia nigra	UBERON:0002038	70.76	gold quality
blood	UBERON:0000178	70.15	gold quality
adult mammalian kidney	UBERON:0000082	70.06	gold quality
vagina	UBERON:0000996	69.65	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.79	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.70	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.59	gold quality
endocervix	UBERON:0000458	67.07	gold quality
nucleus accumbens	UBERON:0001882	66.95	gold quality
transverse colon	UBERON:0001157	66.86	gold quality
ascending aorta	UBERON:0001496	66.68	gold quality
skin of abdomen	UBERON:0001416	65.06	gold quality
putamen	UBERON:0001874	64.99	gold quality
descending thoracic aorta	UBERON:0002345	64.89	gold quality
lung	UBERON:0002048	64.86	gold quality
skin of leg	UBERON:0001511	64.78	gold quality
cerebellar hemisphere	UBERON:0002245	64.29	gold quality
right frontal lobe	UBERON:0002810	63.80	gold quality
amygdala	UBERON:0001876	63.59	gold quality
hypothalamus	UBERON:0001898	63.33	gold quality
pituitary gland	UBERON:0000007	63.13	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.07	gold quality
colon	UBERON:0001155	63.04	gold quality
caudate nucleus	UBERON:0001873	62.94	gold quality
spleen	UBERON:0002106	62.75	gold quality
left testis	UBERON:0004533	50.21	gold quality
right testis	UBERON:0004534	49.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.