MIR1290

Summary

MIR1290 (microRNA 1290, HGNC:35283) is a microRNA gene on chromosome 1p36.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302276 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35283
Approved symbol	MIR1290
Name	microRNA 1290
Location	1p36.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1290
Ensembl gene	ENSG00000221662
Ensembl biotype	miRNA
Entrez	100302276
RNAcentral	URS000075D458 — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408735

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408735 — 1 exons

Exon	Start	End
ENSE00001565370	18897071	18897148

Expression profiles

Bgee: expression breadth broad, 91 present calls, max score 84.74.

Top tissues by expression

91 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	84.74	gold quality
bone marrow	UBERON:0002371	81.11	gold quality
endometrium	UBERON:0001295	80.47	gold quality
calcaneal tendon	UBERON:0003701	79.23	gold quality
right uterine tube	UBERON:0001302	78.73	gold quality
monocyte	CL:0000576	77.92	gold quality
kidney	UBERON:0002113	75.57	gold quality
muscle of leg	UBERON:0001383	74.51	gold quality
blood	UBERON:0000178	74.44	gold quality
placenta	UBERON:0001987	74.43	gold quality
liver	UBERON:0002107	73.64	gold quality
gastrocnemius	UBERON:0001388	73.34	gold quality
granulocyte	CL:0000094	72.62	gold quality
mucosa of stomach	UBERON:0001199	72.24	gold quality
adult mammalian kidney	UBERON:0000082	72.20	gold quality
islet of Langerhans	UBERON:0000006	71.28	gold quality
stomach	UBERON:0000945	70.96	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.84	gold quality
smooth muscle tissue	UBERON:0001135	70.78	gold quality
right lobe of liver	UBERON:0001114	70.73	gold quality
heart	UBERON:0000948	69.94	gold quality
right atrium auricular region	UBERON:0006631	69.24	gold quality
body of pancreas	UBERON:0001150	68.71	gold quality
lung	UBERON:0002048	68.44	gold quality
tibial artery	UBERON:0007610	68.38	gold quality
right ovary	UBERON:0002118	68.14	gold quality
heart left ventricle	UBERON:0002084	67.88	gold quality
Ammon’s horn	UBERON:0001954	67.82	gold quality
rectum	UBERON:0001052	67.72	gold quality
body of stomach	UBERON:0001161	67.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• miRNA-584 and miRNA-1290, upregulated by the CagA protein of H, pylori, interfere with cell differentiation and are implicated in metaplasia and tissue remodeling. (PMID:22536353)
• up-regulation of miR-1290 in colon cancer cells impaired cytokinesis and affected reprogramming. (PMID:23142292)
• Downregulation of miR-1290 is associated with estrogen receptor alpha-positive breast cancer. (PMID:23183268)
• The detection of elevated circulating miR-1290 has the potential to improve the early detection of pancreatic cancer. (PMID:23697990)
• Knockdown of miR-1290 inhibited differentiation and induced proliferation in differentiated neurons. (PMID:24407235)
• A signature comprising three miRNAs (miR1290, miR196b, and miR135a*) enabled the prediction of a chemotherapeutic response (rather than progression-free and overall survival) with high accuracy in patients with recurring lung adenocarcinoma (PMID:25142144)
• We report that miR-1290 directly targets the NAT1 3’-UTR and that NAT1 protein expression is correlated with improved OS of breast cancer patients. (PMID:25528056)
• antagomir-1290 significantly inhibited the proliferation, clonogenicity, invasion, and migration of CD133(+) cells by targeting fyn-related Src family tyrosine kinase. (PMID:25783528)
• Suggest that miR-1290 may play an oncogenic role in cellular processes of esophageal squamous cell carcinoma. (PMID:25805931)
• MiR-196b and miR-1290 targeted the 3’ untranslated region of HIV-1 and affected its expression. (PMID:26469550)
• Data suggest miR-1290 as the new oncomiR involved in laryngeal squamous cell carcinoma pathogenesis probably through downregulation of its target genes MAF and ITPR2. (PMID:26694163)
• Anti-miR-1246 and anti-miR-1290 suppressed proliferation, sphere-formation, colony formation and invasion of NSCLC. CSCs-associated miR-1246, or miR-1290 may be important in the invasion or metastasis of NSCLC. (PMID:26711929)
• Tumor-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression. (PMID:27325363)
• Serum miR-1290 is a novel biomarker for early detection, recurrence, and prognosis in colorectal cancer (CRC). (PMID:27502702)
• AA can protect cardiomyocytes against hypoxia-induced apoptosis through regulating the miR-1290/HIF3A/HIF-1alpha axis, and miR-1290 may be a potential target in the prevention of myocardial ischemia-reperfusion injury (PMID:28686797)
• Compared to noncancerous esophageal mucosa, miR-1290 expression was upregulated, while NFIX mRNA expression was downregulated in ESCC tissues. Data suggest that the dysregulation of miR-1290-NFIX axis may play crucial roles in esophageal carcinogenesis and progression. (PMID:28800311)
• Luciferase reporter assay revealed that miR-1290 directly bound to the 3’-UTR of INPP4B; the mutated seed sites in miR-1290 abrogated this effect. Double knockdown of INPP4B and miR-1290 promoted CRC cell proliferation, suggesting miR-1290 promoted CRC cell proliferation by targeting INPP4B. (PMID:28915933)
• The orthotopic implantation model showed that miR-1290 overexpression promoted tumor growth while LHX6 overexpression inhibited it. MiR-1290 could promote glioma cell propagation and metastasis by inhibiting LHX6. (PMID:29226322)
• Data suggest that MIR1290 expression is remarkably upregulated in non-small-cell lung carcinoma tissues compared to adjacent normal lung tissues; IRF2 appears to be a direct target of MIR1290. (MIR1290 = microRNA-1290; IRF2 = interferon regulatory factor-2) (PMID:29275213)
• quantification of miR-1290 as a circulating biomarker for pancreatic cancer (PMID:30401891)
• Overexpression of miR-1290 could suppress IKK1 in pancreatic ductal adenocarcinoma, suggesting that miR-1290 partially controls cell proliferation, invasion, and migration by inhibiting the expression of IKK1 via the p62/ NRF2/MDM2 pathway. (PMID:30463064)
• Plasma miR-1290 is a novel and specific biomarker that can effectively differentiate necrotizing enterocolitis (NEC) cases from neonatal sepsis. (PMID:30529132)
• The results suggest that exosomal miR-1290 enhances gastric cancer cell proliferation and invasion by targeting NKD1 (naked cuticle homolog 1) mRNA and downregulating NKD1 expression. (PMID:31435644)
• Neurons can upregulate Cav-1 to increase intake of endothelial cells-derived extracellular vesicles that attenuate apoptosis via miR-1290. (PMID:31740664)
• MiR-1290 targets CCNG2 to promote the metastasis of oral squamous cell carcinoma. (PMID:31841213)
• Hsa_circ_0056558 regulates cyclin-dependent kinase 6 by sponging microRNA-1290 to suppress the proliferation and differentiation in ankylosing spondylitis. (PMID:33685301)
• MiR-1290 promotes myoblast differentiation and protects against myotube atrophy via Akt/p70/FoxO3 pathway regulation. (PMID:33722298)
• LncRNA-NONHSAT024778 promote the proliferation and invasion of chordoma cell by regulating miR-1290/Robo1 axis. (PMID:33767589)
• Detection significance of miR-3662, miR-146a, and miR-1290 in serum exosomes of breast cancer patients. (PMID:34269309)
• Loss of the MAF Transcription Factor in Laryngeal Squamous Cell Carcinoma. (PMID:34356658)
• Circulating MiR-1290 as a potential diagnostic and disease monitoring biomarker of human gastrointestinal tumors. (PMID:34479528)
• miR-1290 promotes IL-8-mediated vascular endothelial cell adhesion by targeting GSK-3beta. (PMID:34837150)
• The potential role of miR-1290 in cancer progression, diagnosis, prognosis, and treatment: An oncomiR or onco-suppressor microRNA? (PMID:34897783)
• Tissue miR-200c-3p and circulating miR-1290 as potential prognostic biomarkers for colorectal cancer. (PMID:35145164)
• [Effect of miR1290 on the growth of endometrial cancer and the related mechanism]. (PMID:35184456)
• Hsa-miR-1290 is associated with stemness and invasiveness in prostate cancer cell lines by targeting RORA. (PMID:35220610)
• Polymorphism in the human arylamine N-acetyltransferase 1 gene 3’-untranslated region determines polyadenylation signal usage. (PMID:35358480)
• Identification of a novel circ_0001946/miR-1290/SOX6 ceRNA network in esophageal squamous cell cancer. (PMID:35411716)
• miR-1290 modulates the radioresistance of triple-negative breast cancer by targeting NLRP3-mediated pyroptosis. (PMID:35471684)
• Circular_0086414 induces SPARC like 1 (SPARCL1) production to inhibit esophageal cancer cell proliferation, invasion and glycolysis and induce cell apoptosis by sponging miR-1290. (PMID:35549806)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.