MIR1291

Summary

MIR1291 (microRNA 1291, HGNC:35284) is a microRNA gene on chromosome 12q13.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302221 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35284
Approved symbol	MIR1291
Name	microRNA 1291
Location	12q13.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1291
Ensembl gene	ENSG00000281842
Ensembl biotype	miRNA
Entrez	100302221
RNAcentral	URS000075D26F — ncRNA, 87 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000627649

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000627649 — 1 exons

Exon	Start	End
ENSE00003772191	48654444	48654530

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 96.53.

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.53	gold quality
calcaneal tendon	UBERON:0003701	87.87	gold quality
lymph node	UBERON:0000029	84.20	gold quality
bone marrow	UBERON:0002371	84.09	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.89	gold quality
adrenal tissue	UBERON:0018303	83.62	gold quality
duodenum	UBERON:0002114	80.28	gold quality
monocyte	CL:0000576	79.31	gold quality
vermiform appendix	UBERON:0001154	78.22	gold quality
placenta	UBERON:0001987	77.06	gold quality
endometrium	UBERON:0001295	74.62	gold quality
muscle of leg	UBERON:0001383	74.49	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.87	gold quality
gastrocnemius	UBERON:0001388	73.78	gold quality
islet of Langerhans	UBERON:0000006	73.74	gold quality
blood	UBERON:0000178	72.82	gold quality
right adrenal gland cortex	UBERON:0035827	72.22	gold quality
body of stomach	UBERON:0001161	72.20	gold quality
stomach	UBERON:0000945	71.90	gold quality
liver	UBERON:0002107	71.89	gold quality
body of pancreas	UBERON:0001150	71.84	gold quality
right lobe of liver	UBERON:0001114	71.19	gold quality
tonsil	UBERON:0002372	70.87	gold quality
heart	UBERON:0000948	70.85	gold quality
right adrenal gland	UBERON:0001233	70.79	gold quality
heart left ventricle	UBERON:0002084	70.77	gold quality
right atrium auricular region	UBERON:0006631	70.45	gold quality
mucosa of transverse colon	UBERON:0004991	70.42	gold quality
adrenal gland	UBERON:0002369	69.81	gold quality
left adrenal gland cortex	UBERON:0035825	69.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• miR-1291 is a biologically relevant regulator of GPC3 expression in hepatoma cells and acts through silencing of the endoplasmic reticulum stress sensor IRE1alpha. (PMID:23598528)
• Hsa-miR-1291 is derived from SNORA34. (PMID:23686318)
• Loss of tumor-suppressive miR-1291 enhanced RCC cell proliferation, migration and invasion through targeting SLC2A1/GLUT1. (PMID:23889809)
• Circulating level of miR-1291 is associated with acute myocardial infarction. (PMID:24885383)
• The role of miR-1291 in human pancreatic carcinoma cell metabolism (PMID:25115443)
• Data identified significantly lower expression of miR-1291 in esophageal squamous cell carcinoma (ESCC) and acts as a tumor suppressor by targeting MUC1. (PMID:26324125)
• Our data showed that miR-1291 was downregulated in a set of clinical pancreatic carcinoma specimens and human pancreatic cancer cell lines (PMID:27322206)
• the findings indicate that miR1291 acts upstream of ArhGAP29 to negatively regulate the RhoA/ROCK1 EMT pathway, ultimately leading to endometrial fibrosis. (PMID:28849001)
• Clinical Impact of Circulated miR-1291 in Plasma of Patients with Liver Cirrhosis (LC) and Hepatocellular Carcinoma (HCC): Implication on Glypican-3 Expression. (PMID:31028536)
• miR-1291 Functions as a Potential Serum Biomarker for Bullous Pemphigoid. (PMID:32399091)
• A novel miR-1291-ERRalpha-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis. (PMID:32641987)
• HCP5, as the sponge of miR-1291, facilitates AML cell proliferation and restrains apoptosis via increasing PIK3R5 expression. (PMID:34187569)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.