MIR1292

Summary

MIR1292 (microRNA 1292, HGNC:35364) is a microRNA gene on chromosome 20p13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302138 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35364
Approved symbol	MIR1292
Name	microRNA 1292
Location	20p13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1292
Ensembl gene	ENSG00000284481
Ensembl biotype	miRNA
OMIM	614155
Entrez	100302138
RNAcentral	URS000075B145 — miRNA, 66 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408135

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408135 — 1 exons

Exon	Start	End
ENSE00001564770	2652777	2652842

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 67.53.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
amygdala	UBERON:0001876	67.53	gold quality
tibial artery	UBERON:0007610	66.12	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.11	gold quality
esophagus mucosa	UBERON:0002469	63.71	gold quality
left adrenal gland cortex	UBERON:0035825	63.52	gold quality
gastrocnemius	UBERON:0001388	63.30	gold quality
nucleus accumbens	UBERON:0001882	62.91	gold quality
brain	UBERON:0000955	62.37	gold quality
right frontal lobe	UBERON:0002810	62.35	gold quality
left lobe of thyroid gland	UBERON:0001120	56.33	gold quality
omental fat pad	UBERON:0010414	55.71	gold quality
thoracic mammary gland	UBERON:0005200	55.27	gold quality
vagina	UBERON:0000996	49.67	gold quality
right ovary	UBERON:0002118	45.98	gold quality
upper lobe of left lung	UBERON:0008952	44.27	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	43.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Circ-IP6K2 suppresses tumor progression by modulating the miR-1292-5p/CAMK2N1 signal in clear cell renal cell carcinoma. (PMID:38980439)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.