MIR1293

Summary

MIR1293 (microRNA 1293, HGNC:35286) is a microRNA gene on chromosome 12q13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302220 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35286
Approved symbol	MIR1293
Name	microRNA 1293
Location	12q13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1293
Ensembl gene	ENSG00000221604
Ensembl biotype	miRNA
Entrez	100302220
RNAcentral	URS000075DE57 — ncRNA, 71 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408677

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408677 — 1 exons

Exon	Start	End
ENSE00001565312	50234142	50234212

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 80.18.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	80.18	gold quality
adrenal tissue	UBERON:0018303	77.66	gold quality
kidney	UBERON:0002113	77.17	gold quality
muscle of leg	UBERON:0001383	74.47	gold quality
endometrium	UBERON:0001295	74.22	gold quality
stomach	UBERON:0000945	72.90	gold quality
gastrocnemius	UBERON:0001388	72.87	gold quality
heart left ventricle	UBERON:0002084	71.12	gold quality
ascending aorta	UBERON:0001496	69.82	gold quality
putamen	UBERON:0001874	69.63	gold quality
right adrenal gland cortex	UBERON:0035827	69.32	gold quality
blood	UBERON:0000178	69.10	gold quality
right atrium auricular region	UBERON:0006631	69.01	gold quality
adrenal gland	UBERON:0002369	67.84	gold quality
body of pancreas	UBERON:0001150	67.69	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.05	gold quality
fundus of stomach	UBERON:0001160	66.83	gold quality
intestine	UBERON:0000160	66.63	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.60	gold quality
omental fat pad	UBERON:0010414	66.28	gold quality
thoracic mammary gland	UBERON:0005200	66.04	gold quality
transverse colon	UBERON:0001157	66.03	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.99	gold quality
body of stomach	UBERON:0001161	65.79	gold quality
minor salivary gland	UBERON:0001830	65.62	gold quality
colon	UBERON:0001155	65.49	gold quality
tibial artery	UBERON:0007610	65.37	gold quality
myometrium	UBERON:0001296	65.15	gold quality
esophagus	UBERON:0001043	64.93	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• hsa-mir-3199-2 and hsa-mir-1293 that can act as prognostic biomarkers of Papillary renal cell carcinoma were screened out, which can provide new insights for the clinical treatment of the disease. (PMID:28338236)
• miR-1293 Suppresses Tumor Malignancy by Targeting Hydrocyanic Oxidase 2: Therapeutic Potential of a miR-1293/Hydrocyanic Oxidase 2 Axis in Renal Cell Carcinoma. (PMID:31971830)
• Identification of Three Differentially Expressed miRNAs as Potential Biomarkers for Lung Adenocarcinoma Prognosis. (PMID:31976830)
• miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway. (PMID:32320642)
• miR-1293 suppresses osteosarcoma progression by modulating drug sensitivity in response to cisplatin treatment. (PMID:38367464)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.