MIR1294

Summary

MIR1294 (microRNA 1294, HGNC:35287) is a microRNA gene on chromosome 5q33.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302181 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35287
Approved symbol	MIR1294
Name	microRNA 1294
Location	5q33.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1294
Ensembl gene	ENSG00000221430
Ensembl biotype	miRNA
Entrez	100302181
RNAcentral	URS000075E3DB — miRNA, 142 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408503

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408503 — 1 exons

Exon	Start	End
ENSE00001565138	154347106	154347247

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 64.72.

Top tissues by expression

5 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	64.72	gold quality
right adrenal gland	UBERON:0001233	61.91	gold quality
sural nerve	UBERON:0015488	58.08	silver quality
left testis	UBERON:0004533	49.77	gold quality
thoracic mammary gland	UBERON:0005200	47.05	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 23)

• Data shows that MiR-1294 was down-regulated in esophageal squamous cell carcinoma and correlates with poor prognosis. Also, miR-1294 suppress esophageal cancer cells proliferation, migration and invasion through targeting c-MYC in vitro. (PMID:25925090)
• Gain function assays showed that miR-1294 overexpression inhibited cell proliferation and cell cycle progression in epithelial ovarian cancer (PMID:30536306)
• miR-1294 functions as a tumor suppressor in OS progression by targeting HOXA9. (PMID:30575897)
• Mechanistically, circular RNA circ_0030235 directly sponges miR-1253 and miR-1294 in pancreatic ductal adenocarcinoma cells. (PMID:30591218)
• Circular RNAs (circRNAs) formed by back-splicing play multiple roles in the occurrence and development of cancer. Hsa_circ_0004370 is involved in the up-regulation of LASP1 by sponging miR-1294. (PMID:30988074)
• Overexpression of circ_0005198 sponges miR-1294 to regulate cell proliferation, apoptosis, migration, and invasion in glioma. (PMID:31038801)
• miR-1294 alleviates epithelial-mesenchymal transition process in gastric cancer by targeting FOXK1. (PMID:31833046)
• Endosomal TLR-8 Senses microRNA-1294 Resulting in the Production of NFkB Dependent Cytokines. (PMID:31867014)
• Arsenic trioxide-induced upregulation of miR-1294 suppresses tumor growth in hepatocellular carcinoma by targeting TEAD1 and PIM1. (PMID:32280078)
• Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome. (PMID:32651991)
• Downregulation of hsa_circ_0000936 sensitizes resistant glioma cells to temozolomide by sponging miR-1294. (PMID:32975228)
• LncRNA TUG1 promotes esophageal cancer development through regulating PLK1 expression by sponging miR-1294. (PMID:33009634)
• circ-PRKCI targets miR-1294 and miR-186-5p by downregulating FOXK1 expression to suppress glycolysis in hepatocellular carcinoma. (PMID:33880589)
• CircRNA UBAP2 serves as a sponge of miR-1294 to increase tumorigenesis in hepatocellular carcinoma through regulating c-Myc expression. (PMID:34314478)
• Circular RNA CircEYA3 induces energy production to promote pancreatic ductal adenocarcinoma progression through the miR-1294/c-Myc axis. (PMID:34419070)
• MiR-1294 suppresses ROS-dependent inflammatory response in atopic dermatitis via restraining STAT3/NF-kappaB pathway. (PMID:34784561)
• Upregulation of exosomal circPLK1 promotes the development of non-small cell lung cancer through the miR-1294/ high mobility group protein A1 axis. (PMID:35114891)
• CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer. (PMID:35168653)
• KLF2-induced circZKSCAN1 potentiates the tumorigenic properties of clear cell renal cell carcinoma by targeting the miR-1294/PIM1 axis. (PMID:35285410)
• CircRNA hsa_circ_0018289 exerts an oncogenic role in cervical cancer progression through miR-1294/ICMT axis. (PMID:35312113)
• Hsa_circ_0023984 Regulates Cell Proliferation, Migration, and Invasion in Esophageal Squamous Cancer via Regulating miR-1294/PI3K/Akt/c-Myc Pathway. (PMID:35522362)
• [The Mechanism of miR-1294 Targeting SOX15 to Regulate Wnt/beta-catenin Signaling Pathway and Promote the Proliferation of Acute Lymphoblastic Leukemia Cells in Children]. (PMID:37096504)
• The tumor suppressor role and ceRNA network of miR-1294 in cancer. (PMID:37303740)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.