MIR1295A

Summary

MIR1295A (microRNA 1295a, HGNC:35288) is a microRNA gene on chromosome 1q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302178 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35288
Approved symbol	MIR1295A
Name	microRNA 1295a
Location	1q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1295
Ensembl gene	ENSG00000221390
Ensembl biotype	miRNA
Entrez	100302178
RNAcentral	URS000075C2E2 — miRNA, 79 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408463

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408463 — 1 exons

Exon	Start	End
ENSE00001565098	171101728	171101806

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 90.86.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	90.86	gold quality
right lobe of liver	UBERON:0001114	89.02	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.57	gold quality
calcaneal tendon	UBERON:0003701	82.60	gold quality
lymph node	UBERON:0000029	79.67	gold quality
monocyte	CL:0000576	77.01	gold quality
muscle of leg	UBERON:0001383	74.61	gold quality
blood	UBERON:0000178	74.16	gold quality
gastrocnemius	UBERON:0001388	73.32	gold quality
endometrium	UBERON:0001295	73.20	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.19	gold quality
tonsil	UBERON:0002372	71.41	gold quality
stomach	UBERON:0000945	71.06	gold quality
fallopian tube	UBERON:0003889	70.52	gold quality
heart	UBERON:0000948	70.46	gold quality
nucleus accumbens	UBERON:0001882	69.78	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.71	gold quality
heart left ventricle	UBERON:0002084	69.55	gold quality
right uterine tube	UBERON:0001302	69.09	gold quality
left adrenal gland	UBERON:0001234	68.78	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.55	gold quality
adipose tissue	UBERON:0001013	68.54	gold quality
right atrium auricular region	UBERON:0006631	68.51	gold quality
body of stomach	UBERON:0001161	68.41	gold quality
left adrenal gland cortex	UBERON:0035825	68.25	gold quality
body of pancreas	UBERON:0001150	67.57	gold quality
right lung	UBERON:0002167	67.32	gold quality
multicellular organism	UBERON:0000468	67.15	gold quality
body of uterus	UBERON:0009853	67.04	gold quality
caudate nucleus	UBERON:0001873	67.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.50

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.