MIR1295B

Summary

MIR1295B (microRNA 1295b, HGNC:43524) is a microRNA gene on chromosome 1q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847009 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43524
Approved symbol	MIR1295B
Name	microRNA 1295b
Location	1q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1295b
Ensembl gene	ENSG00000283598
Ensembl biotype	miRNA
Entrez	100847009
RNAcentral	URS000075D4E4 — miRNA, 60 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636144

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636144 — 1 exons

Exon	Start	End
ENSE00003792751	171101739	171101798

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 79.11.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	79.11	gold quality
skin of abdomen	UBERON:0001416	70.14	gold quality
esophagus mucosa	UBERON:0002469	70.14	gold quality
omental fat pad	UBERON:0010414	65.17	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.72	gold quality
tibial nerve	UBERON:0001323	63.45	gold quality
skin of leg	UBERON:0001511	62.96	gold quality
left adrenal gland cortex	UBERON:0035825	61.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The expression of miR-4478 and miR-1295b-3p were significantly diminished in stool samples of CRC patients with early stage (I, II) in comparison with normal group. (PMID:25519020)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.