MIR1296

Summary

MIR1296 (microRNA 1296, HGNC:35249) is a microRNA gene on chromosome 10q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302150 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35249
Approved symbol	MIR1296
Name	microRNA 1296
Location	10q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1296
Ensembl gene	ENSG00000221063
Ensembl biotype	miRNA
Entrez	100302150
RNAcentral	URS000075CA1B — miRNA, 92 nt, 18 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408136

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408136 — 1 exons

Exon	Start	End
ENSE00001564771	63372957	63373048

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 99.49.

Top tissues by expression

85 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	99.49	gold quality
sural nerve	UBERON:0015488	92.70	gold quality
calcaneal tendon	UBERON:0003701	91.00	gold quality
kidney	UBERON:0002113	89.50	gold quality
corpus callosum	UBERON:0002336	88.66	gold quality
adult mammalian kidney	UBERON:0000082	87.15	gold quality
liver	UBERON:0002107	84.61	gold quality
blood	UBERON:0000178	84.40	gold quality
stomach	UBERON:0000945	81.46	gold quality
adrenal tissue	UBERON:0018303	80.75	gold quality
muscle of leg	UBERON:0001383	78.88	gold quality
bone marrow	UBERON:0002371	78.85	gold quality
heart	UBERON:0000948	75.23	gold quality
monocyte	CL:0000576	74.35	gold quality
right lobe of liver	UBERON:0001114	72.98	gold quality
gastrocnemius	UBERON:0001388	72.94	gold quality
islet of Langerhans	UBERON:0000006	72.86	gold quality
body of pancreas	UBERON:0001150	72.44	gold quality
right ovary	UBERON:0002118	72.05	gold quality
lung	UBERON:0002048	71.94	gold quality
intestine	UBERON:0000160	71.84	gold quality
left coronary artery	UBERON:0001626	71.11	gold quality
adenohypophysis	UBERON:0002196	70.86	gold quality
ectocervix	UBERON:0012249	70.21	gold quality
colon	UBERON:0001155	69.86	gold quality
metanephros cortex	UBERON:0010533	69.62	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.61	gold quality
body of stomach	UBERON:0001161	69.42	gold quality
right atrium auricular region	UBERON:0006631	69.35	gold quality
tibial artery	UBERON:0007610	68.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.75

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• Findings indicate cyclin D1 (CCND1) as a target of microRNA miR-1296. (PMID:26799586)
• miR-1296-5p might be involved in the regulation on the migration and invasion of human gastric cancer cells at least in part via targeting ERBB2/Rac1 signaling pathway. (PMID:28099468)
• Reduced miR-1296 expression confers metastasis and recurrence of hepatocellular carcinoma.SRPK1 is a direct target of miR-1296 in the hepatocellular carcinoma.PI3K/AKT signaling is essential for the biological function of miR-1296 in the epatocellular carcinoma. (PMID:28606154)
• A tumor-suppressive role of miR-1296-5p through the translational repression of oncogenic CDK6 and EGFR in gastric cancer. (PMID:30530570)
• Data show that serum microRNA-1296 is a more sensitive marker of nonalcoholic fatty liver disease (NAFLD) than blood lipids, which provides a new method for noninvasive early screening of NAFLD. (PMID:31625373)
• MicroRNA-1296-5p suppresses the proliferation, migration, and invasion of human osteosarcoma cells by targeting NOTCH2. (PMID:31633240)
• microRNA-1296 Inhibits Glioma Cell Growth by Targeting ABL2. (PMID:33550941)
• Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis. (PMID:34787066)
• Circular RNA hsa_circ_0000519 contributes to angiogenesis and tumor progression in hepatocellular carcinoma through the miR-1296/E2F7 axis. (PMID:36627545)
• Decreased AGGF1 facilitates the progression of placenta accreta spectrum via mediating the P53 signaling pathway under the regulation of miR-1296-5p. (PMID:36753931)
• CircSOD2 polarizes macrophages towards the M1 phenotype to alleviate cisplatin resistance in gastric cancer cells by targeting the miR-1296/STAT1 axis. (PMID:37625563)
• Circ_RPPH1 facilitates progression of breast cancer via miR-1296-5p/TRIM14 axis. (PMID:38816350)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.