MIR1297

Summary

MIR1297 (microRNA 1297, HGNC:35289) is a microRNA gene on chromosome 13q14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302187 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35289
Approved symbol	MIR1297
Name	microRNA 1297
Location	13q14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1297
Ensembl gene	ENSG00000283126
Ensembl biotype	miRNA
Entrez	100302187
RNAcentral	URS000075A88C — miRNA, 77 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637311

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637311 — 1 exons

Exon	Start	End
ENSE00003792286	54311972	54312048

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 76.83.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	76.83	gold quality
blood	UBERON:0000178	76.31	gold quality
right frontal lobe	UBERON:0002810	72.98	gold quality
ascending aorta	UBERON:0001496	69.09	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.70	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.24	gold quality
metanephros cortex	UBERON:0010533	61.78	gold quality
skin of abdomen	UBERON:0001416	61.04	gold quality
lung	UBERON:0002048	59.48	gold quality
spleen	UBERON:0002106	57.98	gold quality
right hemisphere of cerebellum	UBERON:0014890	56.40	gold quality
left testis	UBERON:0004533	39.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 29)

• PTEN was identified to be directly regulated by miR-1297 in laryngeal squamous cell carcinoma. (PMID:22995297)
• results illustrate that miR-511 and miR-1297 act as tumor suppressor genes, which could suppress A549 cell proliferation in vitro and in vivo by suppressing TRIB2 and further increasing C/EBPalpha expression (PMID:23071539)
• High miRNA-1297 expression is associated with testicular germ cell tumor. (PMID:25124605)
• These results imply that miR-1297 has the potential to provide a new approach to colorectal cancer therapy by directly inhibiting Cox-2 expression. (PMID:25422199)
• miR-1297 plays a key role in inhibition of the hepatocellular carcinoma cells proliferation, and enhancing cell apoptosis through targeting EZH2. (PMID:26191190)
• Indicating HMGA2 as the target of miR1297. (PMID:26398017)
• Serum miR-1297 is elevated in healthy controls compared esophageal squamous cell carcinoma patients. (PMID:27152453)
• MiR-1297 is decreased in prostate cancer.MiR-1297 inhibits prostate cancer cell proliferation and invasion.MiR-1297 targets and inhibits AEG-1.MiR-1297 regulates AEG-1/Wnt signaling pathway. (PMID:27746178)
• High miR1297 expression is associated with Non-Small Cell Lung Cancer. (PMID:28872922)
• Low miR1297 expression is associated with Metastasis of Colorectal Cancer. (PMID:28933597)
• SNHG6 promoted expression of MAT2A by suppressing direct binding of miR-1297 to the MAT2A 3’UTR. (PMID:29844127)
• CREB1 overexpression rescued the effects on gastric cancer cell growth induced by miR-1297. (PMID:29870889)
• miR-1297 is up-regulated in melanoma tissues and cell lines (PMID:29873263)
• miR-1297 inhibits the growth and metastasis of pancreatic adenocarcinoma by downregulating MTDH expression (PMID:29908229)
• MicroRNA-1297 contributes to the progression of human cervical carcinoma through PTEN (PMID:29916735)
• Serum was an independent predictive factor of poor outcome at 1 year following aneurysmal subarachnoid hemorrhage (aSAH). This result supports the use of miR-1297 in aSAH to aid determination of prognosis. (PMID:30355655)
• microRNA-1297 promotes the progression of osteoporosis through regulation of osteogenesis of bone marrow mesenchymal stem cells by targeting WNT5A. (PMID:31210281)
• MicroRNA-1297 inhibits proliferation and promotes apoptosis in gastric cancer cells by downregulating CDC6 expression. (PMID:31419217)
• Hsa_circ_0091074 regulates TAZ expression via microRNA1297 in triple negative breast cancer cells. (PMID:32319577)
• CircRNA 001418 Promoted Cell Growth and Metastasis of Bladder Carcinoma via EphA2 by miR-1297. (PMID:32368989)
• Expression level of VLDL receptor and VLDL-c levels in the malignant and benign breast tumors: The correlation with miRNA-4465 and miRNA-1297. (PMID:32711022)
• Development of an immunogenomic landscape for the competing endogenous RNAs network of peri-implantitis. (PMID:33081707)
• Circ_PGPEP1 Serves as a Sponge of miR-1297 to Promote Gastric Cancer Progression via Regulating E2F3. (PMID:33386518)
• MiR-1297 attenuates high glucose-induced injury in HK-2 cells via targeting COL1A2. (PMID:33811432)
• Long noncoding RNA DLGAP1-AS1 promotes the progression of glioma by regulating the miR-1297/EZH2 axis. (PMID:33901010)
• Dual role of microRNA-1297 in the suppression and progression of human malignancies. (PMID:34243098)
• Long non-coding RNA DUXAP8 elevates RCN2 expression and facilitates cell malignant behaviors and angiogenesis in cervical cancer via sponging miR-1297. (PMID:34774078)
• MicroRNA-1297 participates in the repair of intestinal barrier injury in patients with HIV/AIDS via negative regulation of PLCbeta1. (PMID:35608718)
• HCG11 inhibits salivary adenoid cystic carcinoma by upregulating EphA2 via binding to miR-1297. (PMID:36396591)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.