MIR1298

Summary

MIR1298 (microRNA 1298, HGNC:35258) is a microRNA gene on chromosome Xq23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302153 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35258
Approved symbol	MIR1298
Name	microRNA 1298
Location	Xq23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1298
Ensembl gene	ENSG00000221710
Ensembl biotype	miRNA
Entrez	100302153
RNAcentral	URS000075BA87 — miRNA, 112 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408783

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408783 — 1 exons

Exon	Start	End
ENSE00001565418	114715233	114715344

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 77.62.

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.62	gold quality
corpus callosum	UBERON:0002336	75.70	gold quality
tibial artery	UBERON:0007610	71.76	gold quality
right atrium auricular region	UBERON:0006631	70.80	gold quality
transverse colon	UBERON:0001157	70.59	gold quality
right lobe of liver	UBERON:0001114	70.08	gold quality
ascending aorta	UBERON:0001496	69.71	gold quality
esophagus mucosa	UBERON:0002469	69.66	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.62	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.49	gold quality
prostate gland	UBERON:0002367	66.35	gold quality
lung	UBERON:0002048	65.15	gold quality
hypothalamus	UBERON:0001898	65.13	gold quality
skin of abdomen	UBERON:0001416	65.03	gold quality
thoracic mammary gland	UBERON:0005200	64.81	gold quality
tibial nerve	UBERON:0001323	64.53	gold quality
vagina	UBERON:0000996	64.05	gold quality
caudate nucleus	UBERON:0001873	63.41	gold quality
nucleus accumbens	UBERON:0001882	62.98	gold quality
putamen	UBERON:0001874	57.30	gold quality
left testis	UBERON:0004533	47.26	gold quality
right testis	UBERON:0004534	46.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 15)

• demonstrate a specific role of the upstream DNA methylation/miR-1298/Connexin 43 pathway in regulating VSMC function (PMID:26025955)
• Silencing of FAK or LAMB3 recapitulated the synthetic lethal effects of miR-1298 expression in KRAS-driven cancer cells, whereas coexpression of both proteins was critical to rescue miR-1298-induced cell death. (PMID:27698189)
• MicroRNA-1298-5p inhibits cell proliferation and the invasiveness of bladder cancer cells via down-regulation of connexin 43. (PMID:31600451)
• that the downregulation of miR-1298 predicts poor prognosis of non-small cell lung cancer (PMID:31801557)
• MicroRNA-1298-3p inhibits proliferation and invasion of glioma cells by downregulating Nidogen-1. (PMID:32355035)
• microRNA-1298 inhibits the malignant behaviors of breast cancer cells via targeting ADAM9. (PMID:33146718)
• Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer. (PMID:34077306)
• Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6. (PMID:34100174)
• Overexpression of miR-1298 attenuates myocardial ischemia-reperfusion injury by targeting PP2A. (PMID:34351558)
• LncRNA OSER1-AS1 regulates the inflammation and apoptosis of rheumatoid arthritis fibroblast like synoviocytes via regulating miR-1298-5p/E2F1 axis. (PMID:35164656)
• MiR-1298-5p level downregulation induced by Helicobacter pylori infection inhibits autophagy and promotes gastric cancer development by targeting MAP2K6. (PMID:35192930)
• Circular RNA hsa_circ_0119412 contributes to tumorigenesis of gastric cancer via the regulation of the miR-1298-5p/zinc finger BED-type containing 3 (ZBED3) axis. (PMID:35200111)
• The dual role of glioma exosomal microRNAs: glioma eliminates tumor suppressor miR-1298-5p via exosomes to promote immunosuppressive effects of MDSCs. (PMID:35501306)
• MicroRNA-1298-3p induces tumor-suppressive effects in human cervical cancer cells via post-transcriptional suppression of ONECUT2. (PMID:36508388)
• MicroRNA-1298-5p in granulosa cells facilitates cell autophagy in polycystic ovary syndrome by suppressing glutathione-disulfide reductase. (PMID:36781484)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.