MIR1299

Summary

MIR1299 (microRNA 1299, HGNC:35290) is a microRNA gene on chromosome 9p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302167 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35290
Approved symbol	MIR1299
Name	microRNA 1299
Location	9p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1299
Ensembl gene	ENSG00000275377
Ensembl biotype	miRNA
Entrez	100302167
RNAcentral	URS000075D629 — miRNA, 83 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622265

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622265 — 1 exons

Exon	Start	End
ENSE00003714702	40929010	40929092

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 88.10.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	88.10	gold quality
skeletal muscle tissue	UBERON:0001134	86.68	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.23	gold quality
sural nerve	UBERON:0015488	82.27	gold quality
right uterine tube	UBERON:0001302	81.37	gold quality
duodenum	UBERON:0002114	81.21	gold quality
monocyte	CL:0000576	79.09	gold quality
blood	UBERON:0000178	75.90	gold quality
islet of Langerhans	UBERON:0000006	75.55	gold quality
stomach	UBERON:0000945	74.85	gold quality
muscle of leg	UBERON:0001383	74.65	gold quality
gastrocnemius	UBERON:0001388	74.51	gold quality
endometrium	UBERON:0001295	74.41	gold quality
liver	UBERON:0002107	74.25	gold quality
kidney	UBERON:0002113	73.73	gold quality
heart left ventricle	UBERON:0002084	72.77	gold quality
myometrium	UBERON:0001296	71.92	gold quality
calcaneal tendon	UBERON:0003701	71.80	gold quality
heart	UBERON:0000948	71.75	gold quality
adult mammalian kidney	UBERON:0000082	71.54	gold quality
lung	UBERON:0002048	71.54	gold quality
corpus callosum	UBERON:0002336	71.37	gold quality
right adrenal gland	UBERON:0001233	70.97	gold quality
body of pancreas	UBERON:0001150	70.93	gold quality
left uterine tube	UBERON:0001303	70.64	gold quality
right atrium auricular region	UBERON:0006631	70.56	gold quality
tibial artery	UBERON:0007610	70.18	gold quality
endocervix	UBERON:0000458	69.86	gold quality
fundus of stomach	UBERON:0001160	69.86	gold quality
fallopian tube	UBERON:0003889	69.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• miR-1183 and miR-1299 appear to play distinct roles in rheumatic heart disease pathogenesis accompanied by secondary PAH and could be used as potential biological markers for disease development. (PMID:26539505)
• miR-1299 inhibited CDK6 expression and bound to the 3’UTR of CDK6. (PMID:27490780)
• We also confirmed that the overexpression of miR-1299 can not only downregulate the STAT3 pathway, but also inhibited colon cancer cell growth. Our findings could provide new insights into the molecular therapeutic of colon cancer. (PMID:28498395)
• xpression profiles revealed miR-1299 downregulation concomitant with arginase-2 (ARG2) upregulation in hyperpigmented skin of melasma patients. (PMID:28627081)
• Mechanistic studies revealed that ciRS-7 contains 20 miR-1299-binding sites and functions as a ceRNA of miR-1299 in TNBC cells. High expression of ciRS-7 maintains the high migration and invasion properties of TNBC cells by acting as a ceRNA of miR-1299 to enhance the expression of matrix metalloproteinases family members (MMP). (PMID:30072582)
• MiR-1299 functions as a tumor suppressor to inhibit the proliferation and metastasis of prostate cancer by targeting NEK2. (PMID:30720160)
• Circular RNA circ_0005230 could directly sponge miR-1238 and miR-1299 to exert its oncogenic functions in cholangiocarcinoma. (PMID:30946694)
• Upregulation of hsa_circ_0136666 contributes to breast cancer progression by sponging miR-1299 and targeting CDK6. (PMID:30993801)
• MiR-1299 has a role in promoting synthesis and secretion of prolactin by inhibiting FOXO1 expression in drug-resistant prolactinomas, as shown in a model using the rat prolactinoma cell line with human-derived miR-1299 (PMID:31582213)
• circ_ARF3 regulates the pathogenesis of osteosarcoma by sponging miR-1299 to maintain CDK6 expression. (PMID:32240746)
• The circular RNA circMAST1 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-1299 and regulating CTNND1 expression. (PMID:32393764)
• miR1299/NOTCH3/TUG1 feedback loop contributes to the malignant proliferation of ovarian cancer. (PMID:32468036)
• Circular RNA circLIFR regulates the proliferation, migration, invasion and apoptosis of human vascular smooth muscle cells via the miR-1299/KDR axis. (PMID:34705228)
• Circ-METTL15 contributes to the proliferation, metastasis, immune escape and restrains apoptosis in lung cancer by regulating miR-1299/PDL1 axis. (PMID:34796777)
• Hsa_circ_0005230 is up-regulated and promotes gastric cancer cell invasion and migration via regulating the miR-1299/RHOT1 axis. (PMID:35170374)
• circRERE regulates the expression of GBX2 through miR-1299 and ZC3H13/N(6)-methyladenosine (m(6)A) to promote growth and invasion of hepatocellular carcinoma cells. (PMID:36222159)
• A Potential Immune-Related miRNAs Regulatory Network and Corresponding Diagnostic Efficacy in Schizophrenia. (PMID:37100927)
• MiR-1299 is regulated by KCNQ1OT1 and inhibits cervical cancer progression. (PMID:37953567)
• Circulating extracellular vesicle-derived miR-1299 disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A axis in gestational diabetes mellitus. (PMID:39182087)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.