MIR1301

Summary

MIR1301 (microRNA 1301, HGNC:35253) is a microRNA gene on chromosome 2p23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302246 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35253
Approved symbol	MIR1301
Name	microRNA 1301
Location	2p23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1301
Ensembl gene	ENSG00000221445
Ensembl biotype	miRNA
Entrez	100302246
RNAcentral	URS000075BFF2 — miRNA, 82 nt, 14 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408518

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408518 — 1 exons

Exon	Start	End
ENSE00001565153	25328640	25328721

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 85.84.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	85.84	gold quality
blood	UBERON:0000178	79.85	gold quality
muscle of leg	UBERON:0001383	79.35	gold quality
monocyte	CL:0000576	76.72	gold quality
adrenal tissue	UBERON:0018303	75.80	gold quality
gastrocnemius	UBERON:0001388	74.83	gold quality
prefrontal cortex	UBERON:0000451	74.71	gold quality
granulocyte	CL:0000094	73.51	gold quality
heart left ventricle	UBERON:0002084	73.39	gold quality
heart	UBERON:0000948	71.28	gold quality
adult mammalian kidney	UBERON:0000082	71.07	gold quality
kidney	UBERON:0002113	70.85	gold quality
liver	UBERON:0002107	70.45	gold quality
stomach	UBERON:0000945	70.15	gold quality
endometrium	UBERON:0001295	70.14	gold quality
islet of Langerhans	UBERON:0000006	69.84	gold quality
body of pancreas	UBERON:0001150	69.61	gold quality
right atrium auricular region	UBERON:0006631	69.37	gold quality
lung	UBERON:0002048	69.01	gold quality
right adrenal gland cortex	UBERON:0035827	68.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.37	gold quality
body of stomach	UBERON:0001161	68.24	gold quality
putamen	UBERON:0001874	67.94	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.89	gold quality
anterior cingulate cortex	UBERON:0009835	67.80	gold quality
left adrenal gland cortex	UBERON:0035825	67.38	gold quality
left adrenal gland	UBERON:0001234	67.17	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.04	gold quality
right adrenal gland	UBERON:0001233	66.78	gold quality
ascending aorta	UBERON:0001496	66.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 31)

• Results indicate that miR-1301 may be an inhibitor of tumorigenesis in HepG2 cells. (PMID:22159405)
• Data show that MiR-1301 and miR-210 specifically target the tumor suppressive KLF6-FL isoform but not the oncogenic KLF6-SV1 isoform in hepatocellular carcinoma. (PMID:24921656)
• dysregulated in early-onset preeclampsia and could possibly play a role in the regulation of leptin during pregnancy (PMID:25064070)
• RanGAP1 downregulation is associated with drug resistance in Chronic Myeloid Leukemia. (PMID:27228340)
• miR-1301 promoted prostate cancer proliferation by inhibiting PPP2R2C. (PMID:27261573)
• miR-1301 functions as a tumor suppressor that inhibits tumor cell migration and invasion in multiple human cancer cells by regulating the UBE4B-p53 pathway. (PMID:28483517)
• Results suggested that reduced miR-1301 expression could be a promising biomarker for predicting poor survival in glioma patients. (PMID:29077167)
• miR-1301-3p promoted the expansion of prostate cancer stem cells by inhibiting GSK3beta and SFRP1, and activating the Wnt pathway. (PMID:29358129)
• Data show that miR-1301 inhibited the expression of enhancer of zeste homolog 2 protein (EZH2) by binding to the 3’ untranslated regions (3’-UTR) of EZH2 gene. (PMID:29790898)
• miR-1301-3p inhibits cell proliferation via inducing cell cycle arrest and apoptosis through targeting ICT1, and might be a therapeutic target for BC. (PMID:29951881)
• Results found the expression of miR-1301 was significantly down-regulated in osteosarcoma (OS) cells and tissues. Its decreased expression was correlated with malignant clinical features and prognosis. Function analysis showed that miR-1301 overexpression suppressed OS cell migration and invasion. In vitro mechanistic studies revealed that miR-1301 suppressed OS progression via targeting BCL9. (PMID:30172867)
• LINC01433 participated in hepatocellular carcinoma progression through modulating the miR-1301/STAT3 axis (PMID:30317567)
• ABHD11-AS1 acted as a competitive endogenous (ce) RNA to upregulate STAT3 by sponging miR-1301-3p. STAT3-induced lncRNA ABHD11-AS1 promoted papillary thyroid carcinoma progression by regulating PI3K/AKT signalling pathway and miR-1301-3p/STAT3 axis. (PMID:30657221)
• The KLF6 Super Enhancer Modulates Cell Proliferation via MiR-1301 in Human Hepatoma Cells. (PMID:30868974)
• SNHG16 promotes BCL9 expression by sponging miR-1301 to facilitate the proliferation, migration and invasion of OS cells. (PMID:30909141)
• miR-1301 was implicated in the chemosensitivity of osteosarcoma to epirubicin by modulating TRIAP1. (PMID:31433581)
• lncRNA MIAT promotes esophageal squamous cell carcinoma progression by regulating miR-1301-3p/INCENP axis and interacting with SOX2. (PMID:31943174)
• A Novel Three-miRNA Signature Identified Using Bioinformatics Predicts Survival in Esophageal Carcinoma. (PMID:32104700)
• MicroRNA 1301 inhibits cisplatin resistance in human ovarian cancer cells by regulating EMT and autophagy. (PMID:32141535)
• RUNX1-activated upregulation of lncRNA RNCR3 promotes cell proliferation, invasion, and suppresses apoptosis in colorectal cancer via miR-1301-3p/AKT1 axis in vitro and in vivo. (PMID:32239427)
• Long non-coding RNA linc01433 promotes tumorigenesis and progression in esophageal squamous cell carcinoma by sponging miR-1301. (PMID:32432741)
• NEAT1 Decreasing Suppresses Parkinson’s Disease Progression via Acting as miR-1301-3p Sponge. (PMID:32712773)
• Long non-coding RNA plasmacytoma variant translocation 1 (PVT1) promotes glioblastoma multiforme progression via regulating miR-1301-3p/TMBIM6 axis. (PMID:33275233)
• miR-1301-3p suppresses tumor growth by downregulating PCNA in thyroid papillary cancer. (PMID:33454555)
• CTCF-induced upregulation of LINC01207 promotes gastric cancer progression via miR-1301-3p/PODXL axis. (PMID:33495099)
• Long non-coding RNA DANCR modulates osteogenic differentiation by regulating the miR-1301-3p/PROX1 axis. (PMID:33629241)
• Decreased level of miR-1301 promotes colorectal cancer progression via activation of STAT3 pathway. (PMID:33984882)
• Long non-coding RNA LINC01207 promotes cell proliferation and migration but suppresses apoptosis and autophagy in oral squamous cell carcinoma by the microRNA-1301-3p/lactate dehydrogenase isoform A axis. (PMID:34463208)
• Exploring the Study of miR-1301 Inhibiting the Proliferation and Migration of Squamous Cell Carcinoma YD-38 Cells through PI3K/AKT Pathway under Deep Learning Medical Images. (PMID:35186067)
• Long noncoding RNA PVT1 regulates the proliferation and apoptosis of ARPE-19 cells in vitro via the miR-1301-3p/KLF7 axis. (PMID:35451342)
• hsa-miR-1301-3p Promotes the Proliferation and Migration of Nonsmall Cell Lung Cancer Cells and Reduces Radiosensitivity via Targeting Homeodomain-Only Protein Homeobox. (PMID:38156905)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.