MIR1302-1

Summary

MIR1302-1 (microRNA 1302-1, HGNC:35293) is a microRNA gene on chromosome 12q24.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302227 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35293
Approved symbol	MIR1302-1
Name	microRNA 1302-1
Location	12q24.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1302-1
Ensembl gene	ENSG00000283507
Ensembl biotype	miRNA
Entrez	100302227
RNAcentral	URS000075B4ED — ncRNA, 143 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637932

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637932 — 1 exons

Exon	Start	End
ENSE00003792231	112695034	112695176

Expression profiles

Bgee: expression breadth broad, 35 present calls, max score 82.37.

Top tissues by expression

35 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	82.37	gold quality
blood	UBERON:0000178	74.33	gold quality
body of pancreas	UBERON:0001150	73.94	gold quality
heart left ventricle	UBERON:0002084	71.74	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.62	gold quality
gastrocnemius	UBERON:0001388	68.87	gold quality
nucleus accumbens	UBERON:0001882	67.15	gold quality
calcaneal tendon	UBERON:0003701	64.96	gold quality
ascending aorta	UBERON:0001496	64.55	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.09	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.40	gold quality
transverse colon	UBERON:0001157	63.02	gold quality
corpus callosum	UBERON:0002336	62.81	gold quality
esophagus mucosa	UBERON:0002469	62.71	gold quality
substantia nigra	UBERON:0002038	62.57	gold quality
right lobe of thyroid gland	UBERON:0001119	61.86	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.71	gold quality
body of stomach	UBERON:0001161	61.69	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	60.99	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.88	gold quality
cerebellar hemisphere	UBERON:0002245	60.82	gold quality
right frontal lobe	UBERON:0002810	60.36	gold quality
pituitary gland	UBERON:0000007	60.03	gold quality
anterior cingulate cortex	UBERON:0009835	59.60	gold quality
Ammon’s horn	UBERON:0001954	59.16	gold quality
caudate nucleus	UBERON:0001873	59.07	gold quality
tibial nerve	UBERON:0001323	58.72	gold quality
left lobe of thyroid gland	UBERON:0001120	58.67	gold quality
small intestine Peyer’s patch	UBERON:0003454	58.45	gold quality
omental fat pad	UBERON:0010414	58.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (2): MIR1302-8 (ENSG00000221269), MIR1302-6 (ENSG00000221393)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.