MIR1302-3

Summary

MIR1302-3 (microRNA 1302-3, HGNC:35295) is a microRNA gene on chromosome 2q14.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302128 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35295
Approved symbol	MIR1302-3
Name	microRNA 1302-3
Location	2q14.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1302-3
Ensembl gene	ENSG00000221055
Ensembl biotype	miRNA
Entrez	100302128
RNAcentral	URS000075BD28 — miRNA, 138 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408128

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408128 — 1 exons

Exon	Start	End
ENSE00001807845	113582959	113583096

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 76.67.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	76.67	gold quality
left adrenal gland cortex	UBERON:0035825	71.67	gold quality
blood	UBERON:0000178	70.66	gold quality
body of pancreas	UBERON:0001150	69.17	gold quality
muscle of leg	UBERON:0001383	68.77	gold quality
gastrocnemius	UBERON:0001388	68.13	gold quality
descending thoracic aorta	UBERON:0002345	66.65	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.45	gold quality
endometrium	UBERON:0001295	64.53	gold quality
tibial artery	UBERON:0007610	62.37	gold quality
endocervix	UBERON:0000458	61.93	gold quality
heart left ventricle	UBERON:0002084	60.60	gold quality
stomach	UBERON:0000945	60.41	gold quality
right lung	UBERON:0002167	60.31	gold quality
heart	UBERON:0000948	60.22	gold quality
subcutaneous adipose tissue	UBERON:0002190	59.88	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	59.82	gold quality
body of stomach	UBERON:0001161	59.12	gold quality
skin of leg	UBERON:0001511	58.97	gold quality
minor salivary gland	UBERON:0001830	58.38	gold quality
right hemisphere of cerebellum	UBERON:0014890	58.33	gold quality
esophagus mucosa	UBERON:0002469	58.13	gold quality
cerebellar hemisphere	UBERON:0002245	57.94	gold quality
left adrenal gland	UBERON:0001234	57.35	gold quality
upper lobe of left lung	UBERON:0008952	56.82	gold quality
small intestine Peyer’s patch	UBERON:0003454	56.70	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	56.66	gold quality
skin of abdomen	UBERON:0001416	56.27	gold quality
tibial nerve	UBERON:0001323	56.19	gold quality
right lobe of liver	UBERON:0001114	56.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Study found that the miR-1302-3C>T polymorphism is significantly associated with recurrent implantation failure development in Korean women. (PMID:29739285)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.