MIR1302-4

Summary

MIR1302-4 (microRNA 1302-4, HGNC:35296) is a microRNA gene on chromosome 2q33.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302130 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35296
Approved symbol	MIR1302-4
Name	microRNA 1302-4
Location	2q33.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1302-4
Ensembl gene	ENSG00000221628
Ensembl biotype	miRNA
Entrez	100302130
RNAcentral	URS000075DA79 — miRNA, 150 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408701

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408701 — 1 exons

Exon	Start	End
ENSE00001565336	207269275	207269424

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 80.96.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortex of kidney	UBERON:0001225	80.96	gold quality
monocyte	CL:0000576	76.41	gold quality
blood	UBERON:0000178	70.32	gold quality
gastrocnemius	UBERON:0001388	69.90	gold quality
right lobe of liver	UBERON:0001114	69.35	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.15	gold quality
intestine	UBERON:0000160	65.52	gold quality
ascending aorta	UBERON:0001496	65.47	gold quality
liver	UBERON:0002107	63.81	gold quality
tibial artery	UBERON:0007610	63.16	gold quality
amygdala	UBERON:0001876	62.90	gold quality
esophagus mucosa	UBERON:0002469	61.93	gold quality
body of uterus	UBERON:0009853	61.25	gold quality
caudate nucleus	UBERON:0001873	61.07	gold quality
skin of abdomen	UBERON:0001416	60.73	gold quality
left ovary	UBERON:0002119	59.86	gold quality
endocervix	UBERON:0000458	59.44	gold quality
skin of leg	UBERON:0001511	59.41	gold quality
transverse colon	UBERON:0001157	59.00	gold quality
corpus callosum	UBERON:0002336	58.77	gold quality
hypothalamus	UBERON:0001898	58.24	gold quality
anterior cingulate cortex	UBERON:0009835	57.87	gold quality
omental fat pad	UBERON:0010414	56.36	gold quality
right hemisphere of cerebellum	UBERON:0014890	56.11	gold quality
spleen	UBERON:0002106	54.48	gold quality
adult mammalian kidney	UBERON:0000082	53.33	gold quality
upper lobe of left lung	UBERON:0008952	46.68	gold quality
left testis	UBERON:0004533	39.42	gold quality
right testis	UBERON:0004534	36.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.