MIR1302-5

Summary

MIR1302-5 (microRNA 1302-5, HGNC:35297) is a microRNA gene on chromosome 20q13.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302146 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35297
Approved symbol	MIR1302-5
Name	microRNA 1302-5
Location	20q13.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1302-5
Ensembl gene	ENSG00000221091
Ensembl biotype	miRNA
Entrez	100302146
RNAcentral	URS000075B4EF — miRNA, 150 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408164

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408164 — 1 exons

Exon	Start	End
ENSE00001564799	50614636	50614785

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 74.32.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	74.32	gold quality
adrenal tissue	UBERON:0018303	72.02	gold quality
gastrocnemius	UBERON:0001388	70.53	gold quality
islet of Langerhans	UBERON:0000006	69.13	gold quality
adult mammalian kidney	UBERON:0000082	68.58	gold quality
blood	UBERON:0000178	68.56	gold quality
ectocervix	UBERON:0012249	67.12	gold quality
body of pancreas	UBERON:0001150	66.63	gold quality
body of stomach	UBERON:0001161	66.34	gold quality
myometrium	UBERON:0001296	66.26	gold quality
smooth muscle tissue	UBERON:0001135	65.55	gold quality
heart left ventricle	UBERON:0002084	65.44	gold quality
heart	UBERON:0000948	65.33	gold quality
endometrium	UBERON:0001295	64.89	gold quality
stomach	UBERON:0000945	64.78	gold quality
right lobe of liver	UBERON:0001114	64.65	gold quality
calcaneal tendon	UBERON:0003701	64.52	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.25	gold quality
urinary bladder	UBERON:0001255	64.12	gold quality
liver	UBERON:0002107	63.94	gold quality
ascending aorta	UBERON:0001496	63.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.13	gold quality
adipose tissue	UBERON:0001013	63.04	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.02	gold quality
gall bladder	UBERON:0002110	62.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.54	gold quality
colon	UBERON:0001155	62.46	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.40	gold quality
left coronary artery	UBERON:0001626	62.30	gold quality
omental fat pad	UBERON:0010414	62.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.