MIR1302-6

Summary

MIR1302-6 (microRNA 1302-6, HGNC:35298) is a microRNA gene on chromosome 7p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302140 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35298
Approved symbol	MIR1302-6
Name	microRNA 1302-6
Location	7p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1302-6
Ensembl gene	ENSG00000221393
Ensembl biotype	miRNA
Entrez	100302140
RNAcentral	URS000075BA64 — ncRNA, 90 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408466

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408466 — 1 exons

Exon	Start	End
ENSE00001565101	18127220	18127309

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 81.38.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	81.38	gold quality
blood	UBERON:0000178	79.74	gold quality
lung	UBERON:0002048	76.50	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.71	gold quality
intestine	UBERON:0000160	67.36	gold quality
stomach	UBERON:0000945	65.52	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.94	gold quality
skin of leg	UBERON:0001511	60.33	gold quality
colon	UBERON:0001155	56.19	gold quality
cerebellar hemisphere	UBERON:0002245	55.54	gold quality
pituitary gland	UBERON:0000007	54.64	gold quality
spleen	UBERON:0002106	53.16	gold quality
left testis	UBERON:0004533	40.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (2): MIR1302-8 (ENSG00000221269), MIR1302-1 (ENSG00000283507)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.