MIR1302-7

Summary

MIR1302-7 (microRNA 1302-7, HGNC:35299) is a microRNA gene on chromosome 8q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302147 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35299
Approved symbol	MIR1302-7
Name	microRNA 1302-7
Location	8q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1302-7
Ensembl gene	ENSG00000221768
Ensembl biotype	miRNA
Entrez	100302147
RNAcentral	URS000075C515 — miRNA, 72 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408841

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408841 — 1 exons

Exon	Start	End
ENSE00001565476	141786242	141786313

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 76.80.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	76.80	gold quality
adrenal gland	UBERON:0002369	70.53	gold quality
right adrenal gland	UBERON:0001233	70.18	gold quality
right frontal lobe	UBERON:0002810	69.80	gold quality
small intestine Peyer’s patch	UBERON:0003454	68.65	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.65	gold quality
nucleus accumbens	UBERON:0001882	68.60	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.48	gold quality
left adrenal gland	UBERON:0001234	67.40	gold quality
left adrenal gland cortex	UBERON:0035825	66.89	gold quality
esophagus mucosa	UBERON:0002469	66.81	gold quality
caudate nucleus	UBERON:0001873	65.59	gold quality
putamen	UBERON:0001874	64.28	gold quality
left ovary	UBERON:0002119	64.19	gold quality
anterior cingulate cortex	UBERON:0009835	61.56	gold quality
left lobe of thyroid gland	UBERON:0001120	61.27	gold quality
pituitary gland	UBERON:0000007	55.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.