MIR1302-8

Summary

MIR1302-8 (microRNA 1302-8, HGNC:35300) is a microRNA gene on chromosome 9q22.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302223 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35300
Approved symbol	MIR1302-8
Name	microRNA 1302-8
Location	9q22.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1302-8
Ensembl gene	ENSG00000221269
Ensembl biotype	miRNA
Entrez	100302223
RNAcentral	URS000075EC83 — ncRNA, 128 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408342

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408342 — 1 exons

Exon	Start	End
ENSE00001564977	97363554	97363681

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 90.24.

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	90.24	gold quality
right hemisphere of cerebellum	UBERON:0014890	80.93	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	79.36	gold quality
primary visual cortex	UBERON:0002436	79.21	gold quality
cerebellar hemisphere	UBERON:0002245	78.20	gold quality
skeletal muscle tissue	UBERON:0001134	78.05	gold quality
monocyte	CL:0000576	76.31	gold quality
adrenal tissue	UBERON:0018303	76.13	gold quality
endometrium	UBERON:0001295	75.02	gold quality
blood	UBERON:0000178	74.23	gold quality
left ovary	UBERON:0002119	73.80	gold quality
ovary	UBERON:0000992	73.60	gold quality
vermiform appendix	UBERON:0001154	73.48	gold quality
right ovary	UBERON:0002118	73.46	gold quality
right adrenal gland cortex	UBERON:0035827	73.30	gold quality
lower esophagus mucosa	UBERON:0035834	73.09	gold quality
islet of Langerhans	UBERON:0000006	73.01	gold quality
myometrium	UBERON:0001296	72.85	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.52	gold quality
muscle of leg	UBERON:0001383	72.51	gold quality
right adrenal gland	UBERON:0001233	72.25	gold quality
gastrocnemius	UBERON:0001388	72.20	gold quality
body of uterus	UBERON:0009853	72.17	gold quality
body of pancreas	UBERON:0001150	72.15	gold quality
left coronary artery	UBERON:0001626	72.15	gold quality
right lobe of thyroid gland	UBERON:0001119	72.03	gold quality
left uterine tube	UBERON:0001303	71.43	gold quality
fallopian tube	UBERON:0003889	71.37	gold quality
kidney	UBERON:0002113	71.32	gold quality
descending thoracic aorta	UBERON:0002345	71.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (2): MIR1302-6 (ENSG00000221393), MIR1302-1 (ENSG00000283507)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.