MIR1302-9

Summary

MIR1302-9 (microRNA 1302-9, HGNC:38218) is a microRNA gene on chromosome 9p24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422831 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38218
Approved symbol	MIR1302-9
Name	microRNA 1302-9
Location	9p24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1302-9
Ensembl gene	ENSG00000283921
Ensembl biotype	miRNA
Entrez	100422831
RNAcentral	URS000075CC93 — miRNA, 138 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408365

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408365 — 1 exons

Exon	Start	End
ENSE00001807722	30144	30281

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 62.75.

Top tissues by expression

25 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	62.75	gold quality
gastrocnemius	UBERON:0001388	59.97	gold quality
Ammon’s horn	UBERON:0001954	56.68	gold quality
blood	UBERON:0000178	56.64	gold quality
skin of leg	UBERON:0001511	55.96	gold quality
body of pancreas	UBERON:0001150	52.28	gold quality
tibial nerve	UBERON:0001323	51.37	gold quality
tibial artery	UBERON:0007610	47.64	gold quality
spleen	UBERON:0002106	47.38	gold quality
lower esophagus muscularis layer	UBERON:0035833	46.95	gold quality
hypothalamus	UBERON:0001898	46.86	silver quality
thoracic mammary gland	UBERON:0005200	46.21	gold quality
esophagus mucosa	UBERON:0002469	44.55	gold quality
caudate nucleus	UBERON:0001873	42.70	gold quality
left ovary	UBERON:0002119	41.90	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	41.59	silver quality
body of stomach	UBERON:0001161	41.19	silver quality
vagina	UBERON:0000996	40.99	gold quality
muscle layer of sigmoid colon	UBERON:0035805	40.87	silver quality
transverse colon	UBERON:0001157	40.68	silver quality
small intestine Peyer’s patch	UBERON:0003454	40.19	silver quality
upper lobe of left lung	UBERON:0008952	40.11	silver quality
subcutaneous adipose tissue	UBERON:0002190	39.39	silver quality
omental fat pad	UBERON:0010414	39.04	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	34.93	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (3): MIR1302-11 (ENSG00000283801), MIR1302-2 (ENSG00000284332), MIR1302-10 (ENSG00000284557)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.