MIR1303

Summary

MIR1303 (microRNA 1303, HGNC:35301) is a microRNA gene on chromosome 5q33.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302284 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35301
Approved symbol	MIR1303
Name	microRNA 1303
Location	5q33.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1303
Ensembl gene	ENSG00000221552
Ensembl biotype	miRNA
Entrez	100302284
RNAcentral	URS000075BAB0 — miRNA, 86 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408625

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408625 — 1 exons

Exon	Start	End
ENSE00001565260	154685776	154685861

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 85.68.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	85.68	gold quality
bone marrow	UBERON:0002371	79.67	gold quality
adrenal tissue	UBERON:0018303	79.01	gold quality
urinary bladder	UBERON:0001255	77.95	gold quality
muscle of leg	UBERON:0001383	77.64	gold quality
monocyte	CL:0000576	75.92	gold quality
islet of Langerhans	UBERON:0000006	74.68	gold quality
calcaneal tendon	UBERON:0003701	73.98	gold quality
gastrocnemius	UBERON:0001388	73.00	gold quality
kidney	UBERON:0002113	72.54	gold quality
rectum	UBERON:0001052	72.30	gold quality
blood	UBERON:0000178	71.27	gold quality
endometrium	UBERON:0001295	71.02	gold quality
stomach	UBERON:0000945	70.58	gold quality
adult mammalian kidney	UBERON:0000082	70.30	gold quality
putamen	UBERON:0001874	70.29	gold quality
heart	UBERON:0000948	69.94	gold quality
heart left ventricle	UBERON:0002084	69.92	gold quality
body of stomach	UBERON:0001161	68.91	gold quality
liver	UBERON:0002107	68.88	gold quality
body of pancreas	UBERON:0001150	68.39	gold quality
intestine	UBERON:0000160	68.29	gold quality
myometrium	UBERON:0001296	68.29	gold quality
left adrenal gland cortex	UBERON:0035825	68.17	gold quality
colon	UBERON:0001155	68.15	gold quality
right atrium auricular region	UBERON:0006631	68.14	gold quality
amygdala	UBERON:0001876	67.56	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.56	gold quality
skin of leg	UBERON:0001511	67.37	gold quality
adrenal gland	UBERON:0002369	67.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• High miR-1303 is associated with laryngeal squamous cell carcinoma. (PMID:23817697)
• Downregulation of miR-1303 can inhibit proliferation, migration and invasion of gastric cancer cells by targeting CLDN18. (PMID:24647998)
• Five miRNAs were significantly upregulated in type 2 diabetes mellitus patients (p < 0.05) including miR-661, miR-571, miR-770-5p, miR-892b and miR-1303. Moreover, the levels of the five miRNAs were higher in patients with complications than in those without complications. (PMID:26831044)
• miR-1303 promotes neuroblastoma (NB) proliferation by targeting GSK3beta and SFRP1, and might be a target for NB therapy. (PMID:27434867)
• Coxsackievirus A16 infection promoted the degradation of junctional complexes (Claudin4, Claudin5, VE-Cadherin, and ZO-1), likely by downregulating miR-1303 and upregulating MMP9. (PMID:30228270)
• Upregulation of microRNA-1303 is a potential prognostic marker of non-small cell lung cancer. (PMID:32508320)
• LncRNA BCRT1 facilitates osteosarcoma progression via regulating miR-1303/FGF7 axis. (PMID:34102610)
• Regular football training down-regulates miR-1303 muscle expression in veterans. (PMID:34212217)
• Circ-SKA3 Enhances Doxorubicin Toxicity in AC16 Cells Through miR-1303/TLR4 Axis. (PMID:34544967)
• Next generation sequencing reveals miR-431-3p/miR-1303 as immune-regulating microRNAs for active tuberculosis. (PMID:36057384)
• Micro RNA miR-1303 Promotion of Proliferation, Migration and Invasion of Human Liver Cancer Cells Is Enhanced by Low Talin 1 (TLN1) Expression. (PMID:36192016)
• Apelin promotes osteosarcoma metastasis by upregulating PLOD2 expression via the Hippo signaling pathway and hsa_circ_0000004/miR-1303 axis. (PMID:36632453)
• Inhibiting KCNMA1-AS1 promotes osteogenic differentiation of HBMSCs via miR-1303/cochlin axis. (PMID:36717952)
• hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis. (PMID:38126999)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.