MIR1304

Summary

MIR1304 (microRNA 1304, HGNC:35302) is a microRNA gene on chromosome 11q21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302240 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35302
Approved symbol	MIR1304
Name	microRNA 1304
Location	11q21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1304
Ensembl gene	ENSG00000284458
Ensembl biotype	miRNA
Entrez	100302240
RNAcentral	URS000075CBE0 — miRNA, 91 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408243

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408243 — 1 exons

Exon	Start	End
ENSE00001564878	93733674	93733764

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 78.65.

Top tissues by expression

23 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	78.65	gold quality
liver	UBERON:0002107	76.42	gold quality
lung	UBERON:0002048	73.40	gold quality
vermiform appendix	UBERON:0001154	72.42	gold quality
gastrocnemius	UBERON:0001388	71.67	gold quality
bone marrow	UBERON:0002371	71.21	gold quality
blood	UBERON:0000178	70.91	gold quality
leukocyte	CL:0000738	70.81	gold quality
monocyte	CL:0000576	69.42	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.04	gold quality
left adrenal gland	UBERON:0001234	68.53	gold quality
spleen	UBERON:0002106	67.67	gold quality
stomach	UBERON:0000945	66.43	gold quality
body of stomach	UBERON:0001161	65.22	gold quality
adrenal gland	UBERON:0002369	64.49	gold quality
endometrium	UBERON:0001295	63.99	gold quality
tibial artery	UBERON:0007610	63.65	gold quality
skin of leg	UBERON:0001511	63.15	gold quality
caudate nucleus	UBERON:0001873	61.58	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.08	gold quality
heart left ventricle	UBERON:0002084	59.67	gold quality
islet of Langerhans	UBERON:0000006	49.79	gold quality
testis	UBERON:0000473	35.74	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• circ_0025033 RNA, miR-1231, and miR-1304 are involved in parathyroid cancer initiation and progression (PMID:30709584)
• Circ-FOXM1 upregulated the level of pancreatic progenitor cell differentiation and proliferation factor (PPDPF) and metastasis-associated in colon cancer 1 (MACC1) by sponging miR-1304-5p, thereby increasing the proliferation and invasion of non-small cell lung cancer cells. (PMID:30954221)
• Circular RNA circ_0074026 indicates unfavorable prognosis for patients with glioma and facilitates oncogenesis of tumor cells by targeting miR-1304 to modulate ERBB4 expression. (PMID:31643077)
• Circ-PRMT5 promotes gastric cancer progression by sponging miR-145 and miR-1304 to upregulate MYC (PMID:31701767)
• In osteosarcoma circ_0102049 functions as a competing endogenous RNA (ceRNA) to competitively sponge miR-1304-5p to upregulate MDM2 expression at posttranscriptional level. (PMID:31727503)
• Circular RNA circ_0067934 exhaustion expedites cell apoptosis and represses cell proliferation, migration and invasion in thyroid cancer via sponging miR-1304 and regulating CXCR1 expression. (PMID:31858554)
• Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes. (PMID:36517516)
• miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway. (PMID:37971062)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.