MIR1305

Summary

MIR1305 (microRNA 1305, HGNC:35303) is a microRNA gene on chromosome 4q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302270 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35303
Approved symbol	MIR1305
Name	microRNA 1305
Location	4q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1305
Ensembl gene	ENSG00000221227
Ensembl biotype	miRNA
Entrez	100302270
RNAcentral	URS000075B9BC — miRNA, 86 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408300

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408300 — 1 exons

Exon	Start	End
ENSE00001564935	182169293	182169378

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 89.16.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	89.16	gold quality
kidney	UBERON:0002113	86.22	gold quality
gastrocnemius	UBERON:0001388	81.21	gold quality
stomach	UBERON:0000945	79.42	gold quality
heart	UBERON:0000948	76.76	gold quality
ovary	UBERON:0000992	72.12	gold quality
adrenal gland	UBERON:0002369	71.34	gold quality
endometrium	UBERON:0001295	70.61	gold quality
monocyte	CL:0000576	70.27	gold quality
intestine	UBERON:0000160	70.18	gold quality
Ammon’s horn	UBERON:0001954	69.72	gold quality
prostate gland	UBERON:0002367	69.59	gold quality
hypothalamus	UBERON:0001898	69.37	gold quality
thoracic mammary gland	UBERON:0005200	68.76	gold quality
heart left ventricle	UBERON:0002084	68.70	gold quality
substantia nigra	UBERON:0002038	67.60	gold quality
putamen	UBERON:0001874	66.11	gold quality
omental fat pad	UBERON:0010414	65.98	gold quality
nucleus accumbens	UBERON:0001882	65.67	gold quality
left adrenal gland	UBERON:0001234	65.31	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.74	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.59	gold quality
right adrenal gland cortex	UBERON:0035827	64.51	gold quality
anterior cingulate cortex	UBERON:0009835	64.50	gold quality
colon	UBERON:0001155	64.36	gold quality
left adrenal gland cortex	UBERON:0035825	64.33	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.31	gold quality
left ovary	UBERON:0002119	63.94	gold quality
lung	UBERON:0002048	63.82	gold quality
cerebral cortex	UBERON:0000956	63.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• These data point to an important role for miR-1305 as a novel regulator of pluripotency. (PMID:27339422)
• results characterized miR-1305-Smad4 axis as a major downstream functional mechanism of lncRNA DANCR in promoting the chondrogenesis in synovium-derived mesenchymal stem cells. (PMID:28674107)
• Circular RNA hsa_circ_0076906 competes with OGN for miR-1305 biding site to alleviate the progression of osteoporosis. (PMID:32087327)
• Hsa_circ_0072008 regulates cell proliferation, migration, and invasion in cervical squamous cell carcinoma via miR-1305/helicase, lymphoid specific (HELLS) axis. (PMID:35311456)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.