MIR1306

Summary

MIR1306 (microRNA 1306, HGNC:35371) is a microRNA gene on chromosome 22q11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302197 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35371
Approved symbol	MIR1306
Name	microRNA 1306
Location	22q11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1306
Ensembl gene	ENSG00000284464
Ensembl biotype	miRNA
Entrez	100302197
RNAcentral	URS000075B769 — miRNA, 85 nt, 22 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408439

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408439 — 1 exons

Exon	Start	End
ENSE00001565074	20086058	20086142

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 80.69.

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	80.69	gold quality
bone marrow	UBERON:0002371	79.81	gold quality
right atrium auricular region	UBERON:0006631	74.29	gold quality
adrenal tissue	UBERON:0018303	73.69	gold quality
pancreas	UBERON:0001264	73.59	gold quality
muscle of leg	UBERON:0001383	70.44	gold quality
blood	UBERON:0000178	69.98	gold quality
prostate gland	UBERON:0002367	67.79	gold quality
adrenal gland	UBERON:0002369	64.91	gold quality
heart left ventricle	UBERON:0002084	62.45	gold quality
islet of Langerhans	UBERON:0000006	61.22	gold quality
small intestine	UBERON:0002108	60.41	gold quality
omental fat pad	UBERON:0010414	59.07	gold quality
nucleus accumbens	UBERON:0001882	58.27	gold quality
Ammon’s horn	UBERON:0001954	57.13	gold quality
subcutaneous adipose tissue	UBERON:0002190	50.71	gold quality
brain	UBERON:0000955	49.26	gold quality
left adrenal gland cortex	UBERON:0035825	48.73	gold quality
putamen	UBERON:0001874	45.17	gold quality
amygdala	UBERON:0001876	44.22	gold quality
right hemisphere of cerebellum	UBERON:0014890	43.91	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	36.62	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• MiR-1306-3p is a tumor enhancer in regulating of hepatocellular carcinoma metastasis.MiR-1306-3p is up-regulated in hepatocellular carcinoma and correlates with poor patients prognosis.MiR-1306-3p inhibited snail protein to enhance its expression via directly targeting FBXL5, thus inducing the epithelial-mesenchymal transition in hepatocellular carcinoma. (PMID:30219228)
• BIK knockdown mimicked, while overexpression reversed the protective effects of miR-1306-5p against OGD/R induced injury (PMID:31460837)
• lncRNASNHG7003 inhibits the proliferation, migration and invasion of vascular smooth muscle cells by targeting the miR13065p/SIRT7 signaling pathway. (PMID:33416100)
• Overexpression of miR-1306-5p, miR-3195, and miR-3914 Inhibits Ameloblast Differentiation through Suppression of Genes Associated with Human Amelogenesis Imperfecta. (PMID:33672174)
• LncRNA DANCR improves the dysfunction of the intestinal barrier and alleviates epithelial injury by targeting the miR-1306-5p/PLK1 axis in sepsis. (PMID:34003569)
• SLCO4A1-AS1 triggers the malignant behaviours of melanoma cells via sponging miR-1306-5p to enhance PCGF2. (PMID:35427425)
• MiR-1306-5p promotes cell proliferation and inhibits cell apoptosis in acute myeloid leukemia by downregulating PHF6 expression. (PMID:35780573)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir1306	ENSDARG00000081904
mus_musculus	Mir1306	ENSMUSG00000080452

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.